Chemwatch: 34-9443
Page 9 of 12
Version No: 4.1.1.1
Issue Date: 02/13/2014
Fido's Fre-Itch Rinse Concentrate For Dogs, Cats, Puppies, Kittens And Cage Birds
Print Date: 06/27/2016
absorbed doses high enough to significantly affect the mixed function oxidase enzymes would be required. It is unlikely that
these levels would occur based on the registered uses of pyrethrins.
Neurotoxicity: There is a concern for neurotoxicity resulting from exposure to pyrethrins, based on
tremors in female rats, decreased motor activity in male rats, and neuropathology in both sexes in a rat acute neurotoxicity
study;
clinical signs (excessive salivation and head arched backward) in a female rabbit following exposure during gestation; and
tremors in female rats in a subchronic inhalation study.
In the range-finding developmental toxicity studies in rats and rabbits, tremors/convulsions were observed in those that died
during the study. In the mouse 90-day range-finding study, tremors and increased/decreased activity were observed at dose
levels that also resulted in mortality. Pyrethrins are axonic poisons.
Reproductive toxicity: In the two generation rat reproduction study, parental male systemic and reproductive toxicity were
detected at 1000 ppm (65 mg/kg body weight per day) and parental female systemic toxicity was detected at 3000 ppm (196
mg/kg body weight per day). The NOAEL for parental systemic (male) and reproductive toxicity was 100 ppm (6.4 mg/kg
body weight-day).
Cancer: Pyrethrins are classified as “Suggestive Evidence of Carcinogenicity, but Not Sufficient to Assess Human
Carcinogenic Potential,” based on the weight-of-the-evidence including
the occurrence of benign liver tumors in female rats,
no treatment-related increase in liver tumors in male rats,
no treatment-related increase in tumors in either sex of mice, and
no concern for mutagenicity.
Endocrine disruption: There is evidence that pyrethrins are associated with endocrine disruption. Direct measurements of
serum thyroid hormones [T3, T4, and TSH], as well as histopathological alterations in the thyroid (i.e. follicular cell
hypertrophy, follicular cell hyperplasia, follicular cell adenomas and/or carcinomas) indicate there is concern regarding the
potential for endocrine disruption When the appropriate screening and/or testing protocols have been developed, pyrethrins
may be subject to additional screening and/or testing.
Pyrethrins and pyrethroids: Pyrethrins are botanical insecticides that come from the pyrethrum flower, Chrysanthemum
cinerariaefolium. Pyrethrins have limitations because of the cost of production and instability in sunlight; therefore, many
synthetic pyrethrins-like compounds were developed to be more stable in sunlight and cost effective. These compounds are
referred to as synthetic pyrethroids. Although all pyrethroids interact with sodium channels, there are multiple types of
sodium channels and it is currently unknown whether the pyrethrins and pyrethroids have similar effects on all channels
NOTE: Studies with rats and mice indicate rapid oxidation of pyrethrin I. Within 48 hrs. metabolites appear in urine (46%) and
in expired CO2 (0.3%) (1). Some unmetabolised substance is found in faeces (2). The synergist, piperonyl butoxide, does not
enhance the acute toxicity of the substance (1). Hutson D.H; Progress in Drug Metabolism 3:215-252 1979 (2). Hayes W.J.;
Pesticide Studies in Man William Wilkins pp 75-80
WATER
No significant acute toxicological data identified in literature search.
Acute Toxicity
Carcinogenicity
Skin
Irritation/Corrosion
Reproductivity
Serious Eye
Damage/Irritation
STOT - Single
Exposure
Respiratory or Skin
sensitisation
STOT - Repeated
Exposure
Mutagenicity
Aspiration Hazard
Legend:
– Data available but does not fill the criteria for classification
– Data required to make classification available
– Data Not Available to make classification
SECTION 12 ECOLOGICAL INFORMATION
Toxicity
Ingredient
Endpoint
Test Duration (hr)
Species
Value
Source
2-ethylhexyl
bicycloheptene
dicarboximide
EC50
48
Crustacea
2.3mg/L
4
2-ethylhexyl
bicycloheptene
dicarboximide
LC50
96
Fish
1.4mg/L
4
piperonyl butoxide
EC50
48
Crustacea
0.1mg/L
4
piperonyl butoxide
LC50
96
Fish
0.0024mg/L
4
piperonyl butoxide
NOEC
48
Crustacea
0.01mg/L
4
piperonyl butoxide
EC50
96
Crustacea
0.23mg/L
2
piperonyl butoxide
EC50
72
Algae or other aquatic plants
0.85mg/L
2
pyrethrin I
EC50
96
Algae or other aquatic plants
0.024mg/L
3