Chemwatch : 22-2369 Version No : 3.1.1.1
Page 8 of 14 Fido ' s Everyday Shampoo
Issue Date : 02 / 13 / 2014 Print Date : 06 / 27 / 2016
SECTION 11 TOXICOLOGICAL INFORMATION
Information on toxicological effects
Inhaled
Ingestion
Skin Contact
Evidence shows , or practical experience predicts , that the material produces irritation of the respiratory system , in a substantial number of individuals , following inhalation . In contrast to most organs , the lung is able to respond to a chemical insult by first removing or neutralising the irritant and then repairing the damage . The repair process , which initially evolved to protect mammalian lungs from foreign matter and antigens , may however , produce further lung damage resulting in the impairment of gas exchange , the primary function of the lungs . Respiratory tract irritation often results in an inflammatory response involving the recruitment and activation of many cell types , mainly derived from the vascular system . Inhalation hazard is increased at higher temperatures .
Considered an unlikely route of entry in commercial / industrial environments Accidental ingestion of the material may be damaging to the health of the individual .
The material may cause skin irritation after prolonged or repeated exposure and may produce a contact dermatitis ( nonallergic ). This form of dermatitis is often characterised by skin redness ( erythema ) and swelling the epidermis . Histologically there may be intercellular oedema of the spongy layer ( spongiosis ) and intracellular oedema of the epidermis . Repeated exposure may cause skin cracking , flaking or drying following normal handling and use . Open cuts , abraded or irritated skin should not be exposed to this material Entry into the blood-stream through , for example , cuts , abrasions , puncture wounds or lesions , may produce systemic injury with harmful effects . Examine the skin prior to the use of the material and ensure that any external damage is suitably protected .
Eye
Chronic
The material may produce severe irritation to the eye causing pronounced inflammation . Repeated or prolonged exposure to irritants may produce conjunctivitis .
Long-term exposure to respiratory irritants may result in disease of the airways involving difficult breathing and related systemic problems . Prolonged or repeated skin contact may cause degreasing with drying , cracking and dermatitis following .
Fido ' s Everyday Shampoo
TOXICITY Not Available
IRRITATION Not Available lauryl sulfate , monoethanolamine salt
TOXICITY Not Available
IRRITATION Not Available formaldehyde solutions - non flammable
TOXICITY Dermal ( rabbit ) LD50 : 270 mg / kg [ 2 ] Inhalation ( rat ) LC50 : 250 ppm / 4hr [ 2 ] Oral ( rat ) LD50 : 100 mg / kg [ 2 ]
IRRITATION Not Available water
TOXICITY Oral ( rat ) LD50 : > 90000 mg / kg [ 2 ]
IRRITATION Not Available
Legend : 1 . Value obtained from Europe ECHA Registered Substances - Acute toxicity 2 .* Value obtained from manufacturer ' s SDS . Unless otherwise specified data extracted from RTECS - Register of Toxic Effect of chemical Substances
LAURYL SULFATE , MONOETHANOLAMINE
SALT
Asthma-like symptoms may continue for months or even years after exposure to the material ceases . This may be due to a non-allergenic condition known as reactive airways dysfunction syndrome ( RADS ) which can occur following exposure to high levels of highly irritating compound . Key criteria for the diagnosis of RADS include the absence of preceding respiratory disease , in a non-atopic individual , with abrupt onset of persistent asthma-like symptoms within minutes to hours of a documented exposure to the irritant . A reversible airflow pattern , on spirometry , with the presence of moderate to severe bronchial hyperreactivity on methacholine challenge testing and the lack of minimal lymphocytic inflammation , without eosinophilia , have also been included in the criteria for diagnosis of RADS . RADS ( or asthma ) following an irritating inhalation is an infrequent disorder with rates related to the concentration of and duration of exposure to the irritating substance . Industrial bronchitis , on the other hand , is a disorder that occurs as result of exposure due to high concentrations of irritating substance ( often particulate in nature ) and is completely reversible after exposure ceases . The disorder is characterised by dyspnea , cough and mucus production . No significant acute toxicological data identified in literature search . for alkyl sulfates ; alkane sulfonates and alpha-olefin sulfonates
Most chemicals of this category are not defined substances , but mixtures of homologues with different alkyl chain lengths . Alpha-olefin sulfonates are mixtures of alkene sulfonate and hydroxyl alkane sulfonates with the sulfonate group in the terminal position and the double bond , or hydroxyl group , located at a position in the vicinity of the sulfonate group . Common physical and / or biological pathways result in structurally similar breakdown products , and are , together with the