Chemwatch : 22-2369 Version No : 3.1.1.1
Page 11 of 14 Fido ' s Everyday Shampoo
Issue Date : 02 / 13 / 2014 Print Date : 06 / 27 / 2016
and 600 mg C12 AS / kg body weight / day by gavage during the most important period of organogenesis ( day 6 to 15 of pregnancy for mice and rats and day 6 to 18 of pregnancy for rabbits ). Reduced litter size , high incidence of skeletal abnormalities and foetal loss were observed in mice at 600 mg C12 AS / kg / day , a dose level which also caused severe toxic effects in the parent animals in all three species . An aqueous solution of 2 % AS was applied ( 0.1 ml ) once daily to the dorsal skin ( 2 x 3 cm ) of pregnant mice from day 1 to day 17 of gestation . A solution of 20 % AS was tested likewise from day 1 to day 10 of gestation . The mice were killed on days 11 and 18 , respectively . A significant decrease in the number of implantations was observed when mice were treated with 20 % AS compared to a control group which was dosed with water . No evidence of teratogenic effects was noted . When aqueous solutions of 2 % and 20 % AS ( 0.1 ml ) were applied once per day to the dorsal skin ( 2 x 3 cm ) of pregnant ICR / Jc1 mice from day 12 to day 17 of gestation no effects on pregnancy outcome were detected . Treatment with 20 % AS resulted in growth retardation of suckling mice , but this effect disappeared after weaning . A 10 % AS solution ( 0.1 ml ) was applied twice daily to the dorsal skin ( 2 x 3 cm ) of pregnant lCR / Jc1 mice during the preimplantation period ( days 0-3 of gestation ). A significant number of embryos collected on day 3 as severely deformed or remained at the morula stage . The number of embryos in the oviducts was significantly greater for the mice dosed with AS as compared to the control mice . No pathological changes were detected in the major organs of the dams
The following information refers to contact allergens as a group and may not be specific to this product . Contact allergies quickly manifest themselves as contact eczema , more rarely as urticaria or Quincke ' s oedema . The pathogenesis of contact eczema involves a cell-mediated ( T lymphocytes ) immune reaction of the delayed type . Other allergic skin reactions , e . g . contact urticaria , involve antibody-mediated immune reactions . The significance of the contact allergen is not simply determined by its sensitisation potential : the distribution of the substance and the opportunities for contact with it are equally important . A weakly sensitising substance which is widely distributed can be a more important allergen than one with stronger sensitising potential with which few individuals come into contact . From a clinical point of view , substances are noteworthy if they produce an allergic test reaction in more than 1 % of the persons tested . No significant acute toxicological data identified in literature search .
The material may produce severe irritation to the eye causing pronounced inflammation . Repeated or prolonged exposure to irritants may produce conjunctivitis .
FORMALDEHYDE SOLUTIONS - NON
FLAMMABLE
Asthma-like symptoms may continue for months or even years after exposure to the material ceases . This may be due to a non-allergenic condition known as reactive airways dysfunction syndrome ( RADS ) which can occur following exposure to high levels of highly irritating compound . Key criteria for the diagnosis of RADS include the absence of preceding respiratory disease , in a non-atopic individual , with abrupt onset of persistent asthma-like symptoms within minutes to hours of a documented exposure to the irritant . A reversible airflow pattern , on spirometry , with the presence of moderate to severe bronchial hyperreactivity on methacholine challenge testing and the lack of minimal lymphocytic inflammation , without eosinophilia , have also been included in the criteria for diagnosis of RADS . RADS ( or asthma ) following an irritating inhalation is an infrequent disorder with rates related to the concentration of and duration of exposure to the irritating substance . Industrial bronchitis , on the other hand , is a disorder that occurs as result of exposure due to high concentrations of irritating substance ( often particulate in nature ) and is completely reversible after exposure ceases . The disorder is characterised by dyspnea , cough and mucus production . The material may produce respiratory tract irritation . Symptoms of pulmonary irritation may include coughing , wheezing , laryngitis , shortness of breath , headache , nausea , and a burning sensation . Unlike most organs , the lung can respond to a chemical insult or a chemical agent , by first removing or neutralising the irritant and then repairing the damage ( inflammation of the lungs may be a consequence ).
The repair process ( which initially developed to protect mammalian lungs from foreign matter and antigens ) may , however , cause further damage to the lungs ( fibrosis for example ) when activated by hazardous chemicals . Often , this results in an impairment of gas exchange , the primary function of the lungs . Therefore prolonged exposure to respiratory irritants may cause sustained breathing difficulties .
The material may produce severe skin irritation after prolonged or repeated exposure , and may produce a contact dermatitis ( nonallergic ). This form of dermatitis is often characterised by skin redness ( erythema ) thickening of the epidermis . Histologically there may be intercellular oedema of the spongy layer ( spongiosis ) and intracellular oedema of the epidermis . Prolonged contact is unlikely , given the severity of response , but repeated exposures may produce severe ulceration .
WATER No significant acute toxicological data identified in literature search .
Acute Toxicity
Skin Irritation / Corrosion
Serious Eye Damage / Irritation
Respiratory or Skin sensitisation
Mutagenicity
Carcinogenicity
Reproductivity
STOT - Single Exposure
STOT - Repeated Exposure
Aspiration Hazard
Legend : – Data available but does not fill the criteria for classification – Data required to make classification available – Data Not Available to make classification
SECTION 12 ECOLOGICAL INFORMATION