Chemwatch: 22-2369
Version No: 3.1.1.1
Page 10 of 14
Fido's Everyday Shampoo
Issue Date: 02/13/2014
Print Date: 06/27/2016
indication for a genotoxic potential of alkyl sulfates in various in vivo studies on mice (micronucleus assay, chromosome
aberration test, and dominant lethal assay).
alpha-Olefin sulfonates were not mutagenic in the Ames test, and did not induce chromosome aberrations in vitro. No
genotoxicity data were available for alkane sulfonates. Based on the overall negative results in the genotoxicity assays with
alkyl sulfates and alpha-olefin sulfonates, the absence of structural elements indicating mutagenicity, and the overall
database on different types of sulfonates, which were all tested negative in mutagenicity assays, a genotoxic potential of
alkane sulfonates is not expected.
Carcinogenicity: Alkyl sulfates were not carcinogenic in feeding studies with male and female Wistar rats fed diets with
C12-15 alkyl sulfate sodium for two years (corresponding to doses of up to 1125 mg/kg/day).
alpha-Olefin sulfonates were not carcinogenic in mice and rats after dermal application, and in rats after oral exposure.
No carcinogenicity studies were available for the alkane sulfonates.
Reproductive toxicity: No indication for adverse