Chemwatch : 4883-41 Version No : 5.1.1.1
Page 8 of 13 Fidos Black Gloss Shampoo ( Fido ' s Black Gloss Shampoo )
Issue Date : 12 / 22 / 2014 Print Date : 06 / 27 / 2016
Shampoo ( Fido ' s Black Gloss Shampoo )
Oral ( Rat ) LD50 : > 2000 mg / kg [ 2 ] Not Available sodium lauryl ether sulfate
TOXICITY Oral ( rat ) LD50 : 1600 mg / kg [ 2 ]
IRRITATION Skin ( rabbit ): 25 mg / 24 hr moderate
TOXICITY IRRITATION cocamidopropylbetaine
Oral ( rat ) LD50 : 2700 mg / kg [ 2 ] Eye : primary irritant * Skin : primary irritant * water
TOXICITY Oral ( rat ) LD50 : > 90000 mg / kg [ 2 ]
IRRITATION Not Available
Legend : 1 . Value obtained from Europe ECHA Registered Substances - Acute toxicity 2 .* Value obtained from manufacturer ' s SDS . Unless otherwise specified data extracted from RTECS - Register of Toxic Effect of chemical Substances
SODIUM LAURYL ETHER SULFATE
No significant acute toxicological data identified in literature search . Alkyl ether sulfates ( alcohol or alkyl ethoxysulfates ) ( AES ) ( syn : AAASD , alkyl alcohol alkoxylate sulfates , SLES ) are generally classified according to Comité Européen des Agents de Surface et leurs Intermédiaires Organiques ( CESIO ) as Irritant ( Xi ) with the risk phrases R38 ( Irritating to skin ) and R36 ( Irritating to eyes ). An exception has been made for AES ( 2-3E0 ) in a concentration of 70-75 % where R36 is substituted with R41 ( Risk of serious damage to eyes ). AES are not included in Annex 1 of the list of dangerous substances of Council Directive 67 / 548 / EEC . Acute toxicity : AES are of low acute toxicity . Neat AES are irritant to skin and eyes . The irritation potential of AES containing solutions depends on concentration . Local dermal effects due to direct or indirect skin contact with AES containing solutions in hand-washed laundry or hand dishwashing are not of concern because AES is not a contact sensitiser and AES is not expected to be irritating to the skin at in-use concentrations . The available repeated dose toxicity data demonstrate the low toxicity of AES . Also , they are not considered to be mutagenic , genotoxic or carcinogenic , and are not reproductive or developmental toxicants . The consumer aggregate exposure from direct and indirect skin contact as well as from the oral route via dishware residues results in an estimated total body burden of 29 ug / kg bw / day . AES are easily absorbed in the intestine in rats and humans after oral administration . Radiolabelled C11 AE3S and C12 AE3S were extensively metabolized in rats and most of the 14C-activity was eliminated via the urine and expired air independently of the route of administration ( oral , intraperitoneal or intravenous ). The main urinary metabolite from C11 AE3S is propionic acid-3- ( 3EO ) -sulfate . For C12 and C16 AE3S , the main metabolite is acetic acid-2- ( 3EO ) -sulfate . The alkyl chain appears to be oxidised to CO2 which is expired . The EO-chain seems to be resistant to metabolism . AES are better tolerated on the skin than , e . g ., alkyl sulfates and it is generally agreed that the irritancy of AES is lower than that of other anionic surfactants . Alkyl chain lengths of 12 carbon atoms are considered to be more irritating to the skin compared to other chain lengths . The skin irritating properties of AES normally decrease with increasing level of ethoxylation . Undiluted AES should in general be considered strongly irritating . Even at concentrations of 10 % moderate to strong effects can be expected . However , only mild to slight irritation was observed when a non-specified AES was applied at 1 % to the skin . Subchronic toxicity : A 90-day subchronic feeding study in rats with 1 % of AE3S or AE6S with alkyl chain lengths of C12-14 showed only an increased liver / body weight ratio . In a chronic oral study with a duration of 2 years , doses of C12-AE3S of 0.005 - 0.05 % in the diet or drinking water had no effects on rats . The concentration of 0.5 % sometimes resulted in increased kidney or liver weight . Subchronic 21-day repeat dose dietary studies showed low toxicity of compounds with carbon lengths of C12-15 , C12-14 and C13-15 with sodium or ammonium alkyl ethoxylates with POE ( polyoxyethylene ) n = 3 . One study indicated that C16-18 POE n = 18 had comparable low toxicity . No-observed-adverse-effect levels ( NOAELs ) range from 120 to 468 mg / kg / day , similar to a NOAEL from a 90-day rat gavage study with NaC12-14 POE n = 2 ( CAS RN 68891-38-3 ), which was reported to be 225 mg / kg / day . In addition , another 90-day repeat dose dietary study with NaC12-15 POE n = 3 ( CAS RN 68424-50-0 ) resulted in low toxicity , with a NOAEL of greater than approximately 50 mg / kg / day ( calculated based on dose of 1000 ppm in diet ). Effects were usually related to hepatic hypertrophy , increased liver weight , and related increases in haematological endpoints related to liver enzyme induction . Reproductive and developmental toxicity : No evidence of reproductive and teratogenic effects was seen in a two-generation study in rats fed with a mixture ( 55:45 ) of AES and linear alkylbenzene sulfonates . Dietary levels of 0.1 , 0.5 , and 1 % were administered to the rats either continuously or during the period of major organogenesis during six pregnancies . No changes in reproductive or embryogenic parameters were observed . Based on this study an overall no-observed-adverse-effect level ( NOAEL ) for systemic effects was 0.1 %, which was 86.6 mg / kg / day for the F0 generation , and 149.5 mg / kg / day for the F1 generation . The NOAEL of 86.6 mg / kg / day was selected as the toxicology endpoint for the chronic risk assessment for the sulfate derivatives . Carcinogenicity : Chronic dietary studies conducted with rats showed no incidence of cancer and no effects at the concentrations tested ( lowest dose tested was ca 75 mg / kg / day ). NOTE : Some products containing AES / SLES have been found to also contain traces ( up to 279 ppm ) of 1,4-dioxane ; this is formed as a by-product during the ethoxylation step of its synthesis . The U . S . Food and Drug Administration recommends that these levels be monitored . The U . S . Environmental Protection Agency classifies 1,4-dioxane to be a probable human carcinogen ( not observed in epidemiological studies of workers using the compound , but resulting in more cancer cases in controlled animal studies ), and a known irritant with a no-observed-adverse-effects level of 400 milligrams per cubic meter at concentrations significantly higher than those found in commercial products . Under Proposition 65 , 1,4-dioxane is classified in the U . S . state of California to cause cancer . The FDA encourages