Fido's Grooming MSDS 84-FP2950_2960_2970 - Black Gloss Shampoo | Page 10

Chemwatch : 4883-41 Version No : 5.1.1.1

Page 10 of 13 Fidos Black Gloss Shampoo ( Fido ' s Black Gloss Shampoo )

Issue Date : 12 / 22 / 2014 Print Date : 06 / 27 / 2016

Absorption of the chemical across dermal and gastrointestinal membranes is possible based on the relatively low molecular weight of the chemical ( 500 Da ) and given that it is a surfactant ( EC , 2003 ). Acute toxicity . Acute oral toxicity studies in rats and mice indicated that the LD50 values of the chemical ( at 30-35.61 % concentration ) ranged from 1800 mg / kg bw ( male rats ) up to 5000 mg / kg bw , with mortalities noted in most studies ( CIR , 2010 ). Of note is an acute oral toxicity study conducted in Sprague-Dawley rats ( 5 / sex ) at a single dose of 1800 mg / kg bw ( formulation containing 35.61 % of the chemical ), where no males but all five females died . Overall , the data suggests that mortality occurs following oral administration of the chemical and that it may be an acute oral toxicant . Therefore , based on these data the chemical may be harmful if swallowed . An acute dermal toxicity study in rats was conducted using 2000 mg / kg bw of a 31 % formulation of the chemical ( CIR , 2010 ). Irritation was observed , but there were no clinical signs of systemic toxicity or mortalities . The lack of effects in this study suggests that the chemical is likely to be of low acute dermal toxicity . Irritation . The chemical has a quaternary ammonium functional group , which is a structural alert for corrosion Numerous skin irritation studies , conducted with formulations containing 7.5-30 % of the chemical , indicated that the chemical has irritant properties . The studies were , in-general , conducted under occlusive conditions , with exposure times of up to 24 hours ( 7.5-10 %). Based on the information available , the chemical is likely to be a skin irritant . Eye irritation studies with the chemical showed that corrosive and necrotic effects occurred at 30 % whereas less severe effects were observed at lower concentrations of 2.3-10 % The chemical is classified with the risk phrase R36 : Irritating to eyes , however , based on studies conducted on the chemical it may be a severe eye irritant . Sensitisation . The chemical has a quaternary ammonium functional group , which is a structural alert for sensitisation ( Conflicting results have been obtained with the chemical in animal studies . Positive results were reported in an LLNA study ( an EC3 value was not reported ). In addition , positive results were obtained in two guinea pig maximisation studies conducted by a single laboratory , the first at 3 % induction and 3 % challenge , and the second at 0.15 % induction and 0.015 % challenge . However , there was no sensitisation in a guinea pig maximisation test when the chemical was tested at 6 % induction and 1 % challenge . In addition , no sensitisation was observed in another test in guinea pigs at 0.75 % induction and 0.02 % challenge . No evidence of sensitisation was reported in a HRIPT on a formulation containing the chemical at 0.6 % concentration ( a 10 % dilution of a ~ 6 % formulation ) with 110 volunteers . In HRIPT studies on formulations containing the chemical , no evidence of sensitisation was reported at concentrations of 1.87 % ( 88 subjects ), 0.93 % ( 93 subjects ), 0.3 % ( 100 subjects ), 1.5-3.0 % ( 141 subjects ), 6.0 % ( 210 subjects ), 0.018 % ( 27 subjects ). However , positive results were observed in provocative studies conducted on formulations containing the chemical ( at 0.3-1 % concentration ), conducted in subjects diagnosed with various forms of contact dermatitis , suggesting that the chemical may cause reactions in sensitive individuals In one study authors note that sensitisation effects of the chemical ( and related compounds ) are most likely due to the impurities , including DMAPA and amidopropyl dimethylamines , however , they do not exclude the possibility of the causing the sensitisation . The potential for skin sensit

WATER No significant acute toxicological data identified in literature search .

Acute Toxicity

Skin Irritation / Corrosion

Serious Eye Damage / Irritation

Respiratory or Skin sensitisation

Mutagenicity

Carcinogenicity

Reproductivity

STOT - Single Exposure

STOT - Repeated Exposure

Aspiration Hazard

Legend : – Data available but does not fill the criteria for classification – Data required to make classification available – Data Not Available to make classification

SECTION 12 ECOLOGICAL INFORMATION

Toxicity

Ingredient Endpoint Test Duration ( hr ) Species Value Source

sodium lauryl ether sulfate

NOEC 48 Fish 0.26mg / L 5

Legend :

Extracted from 1 . IUCLID Toxicity Data 2 . Europe ECHA Registered Substances - Ecotoxicological Information - Aquatic Toxicity 3 . EPIWIN Suite V3.12 - Aquatic Toxicity Data ( Estimated ) 4 . US EPA , Ecotox database - Aquatic Toxicity Data 5 . ECETOC Aquatic Hazard Assessment Data 6 . NITE ( Japan ) - Bioconcentration Data 7 . METI ( Japan ) - Bioconcentration Data 8 . Vendor Data