Farmers Review Africa July/Aug 2017 Farmers Review Africa July/Aug 2017 | Page 19

Our Moldy World- Mycotoxins
Supplement
simulation model. A atoxin for example is hepatotoxic and blood
such as helper T-cells, cytotoxic T-cells,
parameters indicating liver functionality can macrophages and monocytes. is information
Reference tool for in vitro research reveal information to further increase our enables determination of the effect of different
In order to determine the real binding and knowledge on the best way to eliminate its mycotoxins on the immune response in the
inactivation of mycotoxins, simple toxicity. animal and the efficacy of the mycotoxin binder in
measurements in the feed are not sufficient, since Ochratoxins on the other hand are nephrotoxic supporting the animal immune reaction when
the animal itself may in uence the effect and pH and need different biomarkers to investigate encountering mycotoxicosis.
plays an underestimated role in the absorption their effects on kidney impairment. Continuous and desorption of certain binders. A perfect in improvement of knowledge is helping to Fumonisin effect on poultry immune response
vitro model of the animal would eliminate understand the toxic effect of a wide range of In one of the many trials performed in
individual variation and control all other factors. mycotoxins and to develop fast methods to Impextraco's own trial facility in Brazil, 96 male
Of course, there is no such thing as a perfect investigate the efficacy of their mycotoxin Cobb 500 day-old-chicks were contaminated with
model, but the digestive tract has been well eliminator.
fumonisins. e contaminated diet was
studied and several factors are easy to simulate.
formulated by replacing control corn by a
e advantage of this method is that by relatively Impextraco was one of the
simple and constant means the effects of the investing in a spin-off company of the Catholic
rst companies
naturally contaminated corn with Fusarium
mycotoxins.
complete range of factors affecting in vitro results University of Parana to further develop the use is resulted in a nal contamination of 17 ppm
of toxin-binding can be observed. of ow cytometry as a tool to gain information fumonisins. is contaminated birds were
Developing anti-mycotoxin products requires in on the effect of mycotoxins on the animal's compared with control birds, receiving no
vivo research to con rm in vitro observations. immune reaction. Flow cytometry is an contamination and birds receiving the mycotoxin
Alongside partnerships with universities, impedance-based, biophysical technology binder, mixed at 0.2% in the contaminated diet.
Impextraco runs