EireChrom - 2017 Training Courses 1 | Page 5

Peptides and Proteins – 4] Biochromatography: Fundamentals of Structure and Analysis 5 6 7 3 2 1 4 5 10 8 5 15 20 min Course no. SS0-9268 Course summary: The growth in biotherapeutics has heralded a new era of possibilities for drug discovery and patient outcomes, but with this we also see new demands in terms of not only synthesis, characterisation and testing but also from regulatory bodies. This course is ideal for people with experience of small molecule analysis who are soon to become involved with biomolecule work and for those routinely working with biotherapeutics who wish to increase their knowledge of non-denaturing techniques such as GFC and HIC or the latest advances in reversed phase analysis of proteins and peptides. Course outline: 1. Examination of the compositional and functional diversity seen amongst proteins and peptides. 2. Exploration of the range of composition, size and shape that imparts this functional diversity and the differences that permit analytical separation. 3. Overview of the types of characterisation required qualitatively and quantitatively. 4. Strategies that can be employed chemically and analytically to fulfill those requirements in determining profiles for degradation and impurities (Post Translational Modifications or PTMs). 5. Different analytical approaches required for the generation of data typically required by Regulatory. 6. Review of chromatographic fundamentals followed by section focusing on Hydrophobic Interaction Chromatography (HIC). Date: 01. February 2017 – Clonmel Register Today: Online: www.phenomenex.com/IETraining | Tel: 01 247 5405 (Eire) LC