1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
Merck KGaA
Thermo Fisher Scientific
Agilent Technologies
Integrated DNA Technologies (IDT)
GenScript
GeneCopoeia, Inc.
New England Biolabs
Origene Technologies, Inc.
Transposagen Biopharmaceuticals, Inc
Applied StemCell. Inc. (*Financial details might not be captured in case of privately-held
companies or for companies that do not report this information in public domain)
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Repeated off-target and safety studies to restrain the market growth
Reducing the length of the director sequence from 20 to 18 nucleotides can increase specificity up to
5,000 times without affecting cutting efficiency. However, every new CRISPR-based therapy
requires a new sgRNA, safety and off-target studies will need to be performed each time which is
expected to restrain growth of the market.
Key players are looking for licensing with the other companies
The key players operating in the global CRISPR technology market include Addgene, Caribou
Biosciences, Inc., Merck KGaA, Horizon Discovery Group plc,CRISPR THERAPEUTICS, Mirus Bio
LLC, Takara Bio USA, Editas Medicine, Thermo Fisher Scientific, Inc., GE Healthcare Dharmacon
Inc. and Intellia Therapeutics, Inc. Companies are involved in collaborations to gain share in the
market.For instance, Caribou Biosciences develop CRISPR technology in collaboration with the
research based on University of California.
Major strategies used by the players in the market include gaining investments from various
pharmaceutical entities and licensing with other companies. For instance, 2017, Horizon Discovery
Group plc, announced the amendment of its existing license with the company, ERS Genomics. This
amendment allows the company to use CRISPR modified cell lines for Good Manufacturing
Practices (GMP) manufacturing of bio therapeutics.
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