A total of 12,011 subjects were enrolled . Half the participants had a family history of lung cancer . ( Table 3 )
Table 3
“ We found that family history of lung cancer may increase the risk of lung cancer ,” Dr . Chang said . “ The prevalence of lung cancer was 3.3 % and 2.0 % in subjects with and without lung cancer family history , respectively . The TALENT study shows that LDCT screening of people who have never smoked but who have other risk factors may result in a beneficial stage-shift for this population .”
Dr . Chang highlighted other key findings from TALENT as well .
� TALENT T0 lung cancer detection was 2.6 %— higher than NLST ( 1.1 %) and NELSON ( 0.9 )
� Lung cancer detected in TALENT T0 : 96.5 % stage 0-1
� A potential risk prediction model for lung cancer in patients who never smoked was generated
� LDCT lung cancer screening in high-risk patients who never smoked may be feasible
“ Lung cancer in non-smokers is a global rising threat , especially in East Asia ,” Dr . Chang said . “ A risk prediction model is needed for screening this high-risk population — assembling risk factors , including data on air pollution and other carcinogens . Finally , useful biomarkers identified in non-smokers at high risk for lung cancer may be needed . Combining biomarkers with an accurate risk prediction model may improve the clinical use .”
Gee-Chen Chang MD , PhD
ABOUT THE AUTHORS
Erin Jungmeyer , Managing Editor , ILCN