Coronavirus disease (COVID-19) technical guidance by WHO Investigation protocol for COVID-19 | Page 2

Population-based age-stratified seroepidemiological investigation protocol for
COVID-19 virus infection
Protocol summary .................................................................................................................... 3
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Background ..................................................................................................................... 4
1.1 Objectives ................................................................................................................................................ 4
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Study procedures ............................................................................................................. 5
2.1 Study design ............................................................................................................................................ 5
2.2 Study population ..................................................................................................................................... 5
2.3 Eligibility criteria ...................................................................................................................................... 6
2.4 Data collection ........................................................................................................................................ 6
2.5 Specimen collection ................................................................................................................................ 7
2.6 Specimen transport ................................................................................................................................. 7
2.7 Ethical considerations ............................................................................................................................. 8
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Laboratory evaluations .................................................................................................. 10
Statistical analyses ......................................................................................................... 11
4.1 Sample size ............................................................................................................................................ 11
4.2 Epidemiological parameters ................................................................................................................. 11
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Reporting of findings ...................................................................................................... 13
5.1 Reporting ............................................................................................................................................... 13
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References ..................................................................................................................... 14
6.1 Further references for COVID-19 .......................................................................................................... 14
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Acknowledgments ......................................................................................................... 15
Appendices ............................................................................................................................ 16
Appendix A: Sample questionnaires - Population-based age-stratified seroepidemiological
investigation protocol for COVID-19 virus infection ................................................................. 16
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