COMPASS Research Report | Page 16

Page 13 growth and are extensively shed by tumour cells . The Verita isolation platform from Biological Dynamics detected 96 % of stage 1 pancreatic cancers using EV .
Figure 12 : Liquid biopsy methods
Source : goetzpartners Research , Created with BioRender . com
Genetic syndromes associated with cancer drastically increase a patient ’ s risk of developing cancer
Genetic testing should inform surveillance programs Due to the decreasing costs of sequencing a patient ’ s genome , companies are increasingly offering cancer-specific inherited genetic risk tests . Saliva-based tests screen for inherited genes that predispose an individual to cancer as shown in ( Table 3 ). Most of these syndromes have a very high lifetime risk of developing cancer and if found should be used for more intensive surveillance programs . Liquid biopsy could have an important follow-up role in these and could cut down on invasive follow up tests .
Table 3 : Inherited cancer tests Gene / Syndrome
Cancer
Lifetime risk
BRCA
Breast , ovarian , pancreatic , prostate
50 % - 80 %
Lynch
Bowel , endometrial , ovarian , gastric , prostate
70 %
Li-Fraumeni Syndrome
Breast , bone , haematological , sarcoma , brain , adrenal
90 % - 100 %
Pten Hamartoma Syndrome
Breast , thyroid , endometrial , bowel , renal , melanoma
85 %
Familial Adenomatous Polyposis
Bowel , gastric , pancreatic , liver
100 % if untreated
Muty Associated Polyposis
Bowel
43 % - 63 %
Peutz Jeghers Syndrome
Breast , bowel , pancreatic , gastric , ovarian
90 %
Von Hippel Lindau Syndrome
Pancreatic , renal
> 60 %
Tuberous Sclerosis
Renal
14 %
Birt-Hogg-Dube Syndrome
Renal
30 %
Multiple Endocrine Neoplasia
Type 1 And 2
Bowel , gastric , adrenal , thyroid
Up to 100 %
Familial Atypical Multiple Mole
Melanoma Syndrome
Melanoma
100 %
Hereditary Papillary Cancer
Renal
100 %
RB1 Gene
Eye
70 %
Juvenile Polyposis Syndrome
Bowel
50 %
Source : goetzpartners Research , BioCentury Inc .
Alongside larger players in genetic testing that test ancestral origin and health associated genes such as 23andMe , there are a few companies offering dedicated inherited cancer testing . These are shown in
Please see analyst certifications , important disclosure information , and information regarding the status of analysts on pages 91-94 of this research report .