side effects (especially with long-term steroid use), and
answering any questions focused around IBD. We are
here to talk about why each medication is prescribed
for IBD and why it is important to take, but it is also
important to think about what medications should not
be included on that medication list.
Yes, the medications that are prescribed to help control
IBD are necessary; however, medications to avoid in IBD
are just as important. IBD involves the gastrointestinal
(GI) tract (AKA the digestive system) where many
medications, when taken by mouth, will travel through
to either be broken down or go somewhere else in the
body to work. Some medications are broken down in
the GI tract and therefore it is important to watch for
these medications that are acting in the GI tract. Since
the digestive system is not working properly, medications that exhibit their effects in the
GI tract may worsen IBD symptoms; in addition, medications that require a functional GI
tract may not be effective in a patient with IBD.
There are many medications that someone with IBD should avoid. Included in this list are
non-steroidal anti-inflammatory drugs (NSAIDs) which are ibuprofen (Advil) or naproxen
(Aleve). NSAIDs are common over-the-counter medications that are typically used for
pain relief and also for the anti-inflammatory effects. The reason these medications
should be avoided is because they may increase the risk of causing a flare or worsen
symptoms of IBD. Also, NSAIDs can be unfavorable on the stomach and have the
potential to cause stomach ulcers. Since the GI tract is already compromised in IBD,
the protective mechanism in the stomach against NSAIDs is also compromised; thus
patients with IBD are more at risk for ulcers or worsening of IBD symptoms if NSAIDs are
used. It is important to understand how and why certain medications may act different in
patients with IBD. Pharmacists play a significant part in helping patients understand their
medications. Pharmacists are advocates for the care of patients, do not hesitate to walk
up to the pharmacy counter and meet your local pharmacist!
Angela Dimos, PharmD Candidate 2014
Northeast Ohio Medical University
Rootstown, Ohio
34