Student Poster Presentation # 20( Session 2)
Oleyl Poly( Ethylene Glycol) Ether Grafted Microdevices for Cellborne Drug Delivery
Student Poster Presentation # 20( Session 2)
Oleyl Poly( Ethylene Glycol) Ether Grafted Microdevices for Cellborne Drug Delivery
Abstract
Yu Miao 1, Hailing Liu 1, Yi Ren 2, Hoyong Chung 1, Jingjiao Guan 1
1 Department of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Florida
State University, 2525 Pottsdamer Street, Tallahassee, Florida, 32310, USA. 2 College of Medicine, Florida State University, 1115 West Call Street, Tallahassee, Florida, 32306, USA
Integrating a cell with artificial micro / nanodevices into a single entity can make a hybrid system that possesses both the functionalities of the cell and the micro / nanodevices, which can serve as a novel drug delivery system. Researchers have utilized different kinds of interactions to make cell / micro or nanodevices complexes such as avidin-biotin, maleimide-thiol, CD44-hyaluronic acid and electrostatic force. However, due to the requirement of specific interactions, these methods are not suitable for all therapeutic cells. Additionally, some of them may be harmful to the bound cells. In order to solve these problems, we covalently grafted oleyl-o-poly( ethylene glycol)-succinyl-N-hydroxy-succinimidyl esters to one side of the microdevice. This molecule has a long carbon chain which can insert into cell’ s membrane and anchoring the microdevice to the cells. Because this interaction is more general, it can be used for many kinds of cells without the prerequisite of having specific functional groups presented on the cell’ s membrane. Non-covalently bonding mechanism also makes it less harmful to cells.
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