CARTA Newsletter (July-Dec 2017) CARTA NEWSLETTER July Dec 2017 | Página 4

Scientific breakthrough Study by CARTA fellow critical in malaria research By Eunice Kilonzo, CARTA communications officer Nearly nine in every 10 new malaria infections in rural Tanzania are transmitted by the Anopheles funestus mosquito. This is despite its smaller population in comparison to other mosquito species, a new study by a CARTA fellow shows. highest levels of endemnicity across sub- Saharan Africa are facing massive shortages in their ability to prevent and respond to the disease. How to manage disease burden and reduce mortality from malaria were major questions confronting heads of state and government at the January summit of African Union leaders. Anopheles funestus is responsible for 82-95% of local malaria infections. Unfortunately, the vector is also resistant to pyrethroids (insecticide) used on bednets. It survives unexpectedly longer, has a highly cryptic Paper Title: Interventions that effectively target Anopheles funestus mosquitoes could significantly improve control of persistent malaria transmission in south–eastern Tanzania Emmanuel Kaindoa, Cohort Five fellow from the Ifakara Health Institute (IHI), demonstrated that while different mosquito species (Anopheles arabiensis) dominate in numbers, a far more competent vector (Anopheles funestus) now transmits most of the residual malaria parasites, despite occurring in far smaller numbers. aquatic ecology, and bites people both indoors and outdoors. These research findings are critical as globally, one child dies from malaria every two minutes, according to the World Health Organization, even as the countries with the Monthly mosquito sampling was carried out between January 2015 and January 2016, in randomly selected households in three villages using Centers for Disease Control and Prevention (CDC) light traps and back-pack aspirators. The sampling was conducted four years after the last mass distribution of long- lasting insecticidal bednets (LLINs). In rural southeastern Tanzania, where malaria prevalence has reduced by more than 60% since 2000, low-to-moderate transmission still persists despite very high coverage with LLINs. Like in most residual transmission settings within East Africa, populations of the formerly notorious malaria vector (known as, Anopheles gambiae), have significantly diminished or completely vanished. As a direct impact of the findings, Ifakara Health Institute has initiated two major research initiatives funded by the Bill & Melinda Gates Foundation, according to the director of science at IHI, Dr. Fredros Okumu. The scientific breakthrough will facilitate the development of new approaches that specifically target the mosquito species, with the aim of drastically reducing residual transmission. More about the Research Paper Authors: Emmanuel W. Kaindoa , Nancy S. Matowo, Halfan S. Ngowo, Gustav Mkandawile, Arnold Mmbando, Marcelina Finda, Fredros O. Okumu Published: May 18, 2017 How talking about mosquitoes opened me up to potential collaborations in the US By Emmanuel Kaindoa CARTA Cohort Five fellow from University of the Witwatersrand, South Africa. I was excited about my trip to the American Society of Tropical Medicine and Hygiene (ASTMH) meeting in Baltimore, United States in November 2017. This was a great opportunity to meet fellow researchers and experienced scientists in global health. I was not disappo