CARDIOVASCULAR RESEARCH : CLINICAL TRIALS
CARDIOVASCULAR RESEARCH : CLINICAL TRIALS
ISCHEMIC HEART DISEASE
Trial : The STEMI DTU Trial PI : Sam McElwee , MD Brief Synopsis : Primary left ventricular unloading and a 30-minute delay to reperfusion vs . current standard of care in reducing infarct size and heart failure-related clinical events in patients presenting with anterior ST-elevation myocardial infarction
Trial : Protect IV PI : Mustafa Ahmed , MD Brief Synopsis : Impella ® -supported PCI in high-risk patients with complex coronary artery disease and reduced left ventricular function
HEART FAILURE
Trial : Array PI : Jose Tallaj , MD Brief Synopsis : To evaluate the effect of ARRY- 371797 on functional capacity as measured by the 6-minute walk test compared to placebo in patients with symptomatic DCM due to a LMNA gene mutation
Trial : Spirrit-HFpEF PI : Andrew Lenneman , MD Brief Synopsis : Spironolactone initiation registry randomized interventional trial in heart failure with preserved ejection fraction
Trial : Anthem HFrEF PI : Jose Tallaj , MD Brief Synopsis : Autonomic regulation therapy using the VITARIA system to enhance myocardial function and reduce progression of heart failure with reduced ejection fraction
VALVE DISEASE
Trial : Repair MR PI : Mustafa Ahmed , MD Brief Synopsis : Percutaneous MitraClip™ device or surgical mitral valve repair in patients with primary mitral regurgitation who are candidates for surgery
Trial : The Early Feasibility of the TTVR Transfemoral System PI : Mustafa Ahmed , MD Brief Synopsis : Evaluation of the safety and performance of the Medtronic Intrepid™ transcatheter tricuspid valve replacement system with transfemoral access in patients with symptomatic severe tricuspid regurgitation
Trial : ACURATE IDE PI : Mustafa Ahmed , MD Brief Synopsis : Transcatheter replacement of stenotic aortic valve through implantation of ACURATE in subjects indicated for TAVR
CARDIAC RHYTHM DISORDERS
Trial : Champion AF PI : Tom McElderry , MD Brief Synopsis : To determine if left atrial appendage closure with the WATCHMAN FLX device is a reasonable alternative to non-vitamin K oral anticoagulants ( NOACs ) in patients with non-valvular atrial fibrillation
Trial : ADVENT PI : Tom McElderry , MD Brief Synopsis : Pivotal trial of the FARAPULSE pulsed field ablation system compared with standard of care ablation in patients with paroxysmal atrial fibrillation
18 UAB Cardiovascular Institute Annual Report