CardioSource WorldNews - Page 14

CLINICAL NEWS JOURNAL WRAP Kim Eagle, MD, and the editors of ACC.org, present relevant articles taken from various journals. PRECISION: Is Celecoxib Non-Inferior to Ibuprofen or Naproxen? Healthy Lifestyle Significantly Reduces CV Risk Regardless of Genetic Risk Adherence to a healthy lifestyle was associated with a significantly reduced risk of coronary artery disease regardless of genetic risk, according to results from a study presented during AHA 2016 and simultaneously published in the New England Journal of Medicine. Researchers quantified genetic risk for coronary artery disease in 55,685 participants across 4 studies (the Atherosclerosis Risk in Communities Study, the Women’s Genome Health Study, the Malmo Diet and Cancer Study and the BioImage Study) using a polygenic risk score. Additionally, they determined adherence to a healthy lifestyle based on 4 factors: no current smoking, no obesity, regular physical activity and a healthy diet. Overall results showed the relative risk of coronary events was 91% higher among high genetic risk patients than those at low genetic risk, independent of healthy lifestyle 12 CardioSource WorldNews behaviors. However, healthy lifestyle factors did prove to significantly reduce risk of coronary artery disease across all genetic risk categories. In those at highest genetic risk, researchers saw a 46% lower relative risk of coronary