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CLINICAL NEWS JACC in a FLASH Featured topics in the current and recent issues of the JACC family of journals ence and extent of atherosclerosis were associated with the extent of secondhand tobacco smoke exposure even when adjusted for other risk factors, further demonstrating the causal relationship of secondhand tobacco smoke exposure and coronary disease.” In an accompanying editorial comment, Khurram Nasir, MD, MPH, and Jaideep Patel, MD, note that “although the study sample size is modest, the initial insights are astounding.” They add that the study provides an opportunity to caution the public against the effects of secondhand smoke and to encourage policymakers to further advance efforts to implement smoke-free laws, especially in public spaces. Yankelevitz DF, Cham MD, Hecht H, et al. J Am Coll Cardiol Img. 2016;doi:10.1016/j. jcmg.2016.07.003 More to Secondhand Smoke Than Previously Thought? There may be a greater association between the extent of secondhand tobacco smoke exposure and the extent of atherosclerosis than previously thought, according to the results of research presented at AHA 2016 and simultaneously published in JACC: Cardiovascular Imaging. David F. Yankelevitz, MD, et al., analyzed responses from questionnaires of 268 never-smokers between the ages of 40 – 80 on their exposure to secondhand tobacco smoke during their lifetime. Researchers used low-dose nongated computed tomographic (CT) ACC.org/CSWN scans, followed by CT angiography, to derive ordinal coronary artery calcium scores, which were then evaluated for characteristics of atherosclerosis. The results of the study show that coronary atherosclerosis was noted in 48%of patients and was more frequent with low to moderate and high vs. minimal secondhand tobacco smoke exposure (48% and 69% vs. 25%). Further, as the reported exposure to secondhand tobacco smoke increased, the percentage of major vessel with any plaque or stenosis increased. The authors conclude that “the pres- POSEIDON-DCM: A Closer Look at Allogenic vs. Autologous Stem Cells Allogenic human mesenchymal stem cells may be safe and effective in patients with non-ischemic dilated cardiomyopathy compared to autologous stem cells, according to the results of the POSEIDON-DCM Trial presented during AHA 2016 and simultaneously published in JACC. Joshua M. Hare, MD, et al., randomized 37 patients with non-ischemic dilated cardiomyopathy to receive either allogenic or autologous bone marrowderived human mesenchymal stem cells by transendocardial stem cell injection. Patients were evaluated at baseline, 30days, 3, 6 and 12 months for safety and efficacy endpoints. The results of the study show that the rate of major adverse cardiac events was lower in patients who re- ceived allogenic stem cells versus autologous. Ejection fraction increased in the allogenic group by 8 units, compared to 5.4 units in the autologous group. Further, at 12-months, the incidence of serious adverse events was 28.2% in the allogenic group versus 63.5% i n the autologous group. “The findings must be viewed as preliminary given the small number of patients enrolled,” commented Kim A. Eagle, MD, editor-in-chief of ACC.org. Hare JM, DiFede DL, Castellanos AM, et al. J Am Coll Cardiol. 2016;doi:10.1016/j. jacc.2016.11.009 Does A Focus on 30-Day HF Readmission Rates Improve Outcomes, Quality of Care? Quality of care and clinical outcomes were comparable among hospitals with high vs. low risk-adjusted 30-day heart failure (HF) readmission rates, according to the results of research presented during AHA 2016 and simultaneously published in JACC: Heart Failure. The findings raise questions about the impacts of the Centers for Medicare and Medicaid Services (CMS) 30-day readmission metric on patient outcomes and quality of care. Researchers analyzed data from 171 centers enrolled in the GWTG-HF Registry linked to Medicare claims from July 2008 to June 2011. Publically available data on HF-excess readmission ratio in 2013 were stratified into two groups based on low vs. high risk-adjusted readmission rates. Care quality, in-hospital, and one-year clinical outcomes were compared across the two groups in unadjusted and multivariable adjusted analysis. Overall results found that 84 centers (49.%) had higher-than-expected risk- CardioSource WorldNews 9