CardioSource WorldNews October 2014 | Page 3
HEART FAILURE
SHATTERS
MILLIONS OF LIVES
HEART FAILURE PATIENTS: “STABLE” OR SILENTLY PROGRESSING?
Heart failure is a progressive disease that is characterized by frequent hospital
admissions and high mortality rates:
HEART FAILURE
HOSPITALIZATIONS
OCCUR EVERY YEAR1
OF HEART FAILURE
PATIENTS DIE WITHIN
1 YEAR OF DIAGNOSIS3,4
and rehospitalization
continues to be an issue2
this increases to ~50%
within 5 years3,4
LET’S WORK TOGETHER
TO CHANGE THAT
The neurohormonal imbalance associated with chronic heart failure is a contributing
pathophysiological factor to the progression of the disease. Overactivation of the RAAS
and SNS lead to decline in heart function, and cardiac remodeling; and the normal
counterregulatory beneficial effects of the natriuretic peptide system (ANP/BNP) are
diminished in heart failure.5-7
LET’S WORK TOGETHER TO CHANGE THAT
RAAS=renin-angiotensin-aldosterone system; SNS=sympathetic nervous system; ANP=atrial natriuretic peptide;
BNP=brain natriuretic peptide.
References: 1. Go AS, Mozaffarian D, Roger VR, et al. Heart disease and stroke statistics—2014 update: a report from the American
Heart Association. Circulation. 2014;129(3):e28-e292. 2. Bradley EH, Curry L, Horwitz LI, et al. Hospital strategies associated with
30-day readmission rates for patients with heart failure. Circ Cardiovasc Qual Outcomes. 2013;6(4):444-450. 3. Levy D, Kenchaiah S,
Larson MG, et al. Long-term trends in the incidence of and survival of heart failure. N Eng J Med. 2002;347(18):1397-1402.
4. Roger VL, Weston SA, Redfield MM, et al. Trends in heart failure incidence and survival in a community-based population.
JAMA. 2004;292(3):344-350. 5. Fauci AS, Braunwald E, Kasper DL, et al, eds. Harrison’s Principles of Internal Medicine. 17th ed. New
York, NY: McGraw-Hill; 2008. 6. Boerrigter G, Costello- Boerrigter L, Burnett JC Jr. Alterations in renal function in heart failure. In:
Mann DL. Heart Failure: A Companion to Braunwald’s Heart Disease. 2nd ed. St. Louis: Saunders; 2011. 7. McMurray J, Komajda M,
Anker S, et al. Heart failure: epidemiology, pathophysiology and diagnosis. In: Camm AJ, Lüscher TF, Serruys PW. ESC Textbook of
Cardiovascular Medicine. New York: Oxford University Press; 2009.
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