• In a systematic review of the evidence, investigators collated data for 2,015 pediatric and adult patients, including 12 randomized controlled trials and two observational studies.6 Prophylactic treatment with dexrazoxane, beta-blocker, statin, or angiotensin antagonists all had similar significant efficacy for reducing cardiotoxicity. Clearly, therapies used in both oncology and cardiology are intimately intertwined at the vascular level. ?
REFERENCES 1. Chen J, Long JB, Hurria A, et al. J Am Coll Cardiol. 2012;60:2504-12. http://content.onlinejacc.org/article. aspx?articleid=1389699 2. Schutz FA, Je Y, Richards CJ, Choueiri TK. J Clin Oncol. 2012;30:871-7. 3. Seicean S, Seicean A, Plana JC, et al. J Am Coll Cardiol. 2012;60:2384-90. http://content.onlinejacc.org/article. aspx?articleid=1389315 4. Lenihan DJ. J Am Coll Cardiol. 2012;60;2391-2 http://content.onlinejacc.org/article.aspx?articleid=1389317 5. Bosch X, Rovira M, Sitges M, et al. J Am Coll Cardiol. 2013;61:2355-62. http://content.onlinejacc.org/article. aspx?articleid=1677827 6. Kalam K, Marwick TH. Eur J Cancer. 2013 May 22. [Epub ahead of print]
Take-aways
• Heart failure and cardiomyopathy are commonly seen in patients following cancer therapy. • In older patients, risk of cardiac events is substantially higher than that reported from clinical trials enrolling younger, healthier women. • A number of agents have shown significant and similar efficacy for reducing cardiotoxicity related to cancer therapy, including dexrazoxane, betablockers, statins, and angiotensin antagonists.
Atherosclerosis Across 3,800 Years Of Human History:
The Horus Study Of Four Ancient Populations
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therosclerosis is often considered a hazard of modern life, leading us to yearn for the simpler, healthier lifestyles of old. However, evidence suggests we may be idealizing the past, at least insofar as it applies to ancient civilizations; data suggest life back then wasn’t quite the idyllic setting for CV health we assumed it to be. The Horus study started when cardiologists toured the Egyptian National Museum of Antiquities in Cairo during a medical conference in 2008; they noticed the nameplate of the Pharoah Merenptah, who ruled from 1213–1203 BC. The biographical information noted that Merenptah died at roughl ?????????????????????Q?????????????????????????????????????????????????????????????????????????????????????((??
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