Enzymatic regulation of anandamide and 2-AG in normal brain, and following TBI. 2-AG levels are approximately 1,000-fold higher than anandamide levels in brain. MAGL plays a rate-limited role in the production of AA in brain, lung, and liver (). Arrows represent known TBI-induced changes in eCBs, catabolic and downstream enzymes, and their metabolic products (arrow size has no relation to magnitude of change).
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