$30-80 per day. This is pretty much a show stopper for most patients.
Even if you could afford it, these doses are just hard to find. The reason is that CBD is not very abundant in Cannabis or hemp. There are some strains that produce more CBD, but it’s still not very much. THC-A, on the other hand, is what Cannabis produces readily. In fact, when you buy good old Cannabis flower for whatever purpose, it has nearly no THC in it! What it has is THC-A. And Lots of it. It is only when we heat the THC-A, by cooking or burning it, for examples, that it converts to THC. Using a cold extraction technique, like chilled ethanol, can produce vast amounts of THC-A for use. Yes, you can do this at home!
THC-A is a potent antioxidant. As a result, there may be some rationale for using it as a neuroprotectant in diseases like Alzheimer’s, Parkinson’s, Multiple Sclerosis, ALS (Lou Gehrig's disease or amyotrophic lateral sclerosis), and similar. This has not yet been tested in humans, but the theory is reasonable.
THC-A is a potent anti-inflammatory. In cell culture of human tissue as well as in mouse models of inflammatory bowel disease, THC-A has been shown to be very effective. In fact, it’s felt to be 10-20x as potent as CBD. Further, CBD in high doses can kill affected cells, whereas THC-A does not. So, THC-A is stronger and more effective.
Worth noting as well, CBD is broken down by the liver by an enzyme that breaks down many common conventional medications. As a result, CBD can interact with these medications, sometimes in potentially dangerous ways. For my more complicated patients, this is a significant concern. THC-A, on the other hand, is broken down by an enzyme that is relatively lonely and has not much better to do than take care of the THC-A. As a result, interactions are much less likely.