ISLET TRANSPLANT
2016 ISLET CELL TRANSPLANT RESEARCH HIGHLIGHTS
Identification of novel anti-
inflammatory small molecules to
improve islet cell transplantation
outcomes. The Baylor Dallas
team identified Withaferin A,
a small molecule extracted from
the plant Withania Somnifera as
a promising compound.
Identification and validation of
biomarkers for islet damage.
The Baylor Dallas team
identified microRNA-375 as a
sensitive and specific marker for
islet cell damage using in vitro
and in vivo studies.
continued to be one of the top five programs
in the country. The Liver and Pancreas Disease
Center at Baylor Dallas brings all of the necessary
resources together to manage the pre- and post-
surgery care of islet cell transplant patients.
With a statewide and national reputation for
industry-leading care, the Baylor Dallas islet cell
transplant program receives referrals from a wide
geographic area. A support group of islet cell
transplant patients also meets regularly at Baylor
Dallas. In addition, Baylor Scott & White –
Fort Worth sponsors a Liver and Pancreas Disease
center that provided outpatient evaluation and
disease management of approximately 120 patients
in 2016. Also in 2016, the center offered a unique
service called the quality of life phone survey. It was
conducted with patients to determine the degree to
which their disease was impacting their lives.
Analysis of cell signaling
pathways critical for islet cell
survival. The Baylor Dallas team
analyzed the role of NFAT, a
transcription factor, in mediating
islet cell inflammation.
ISLET CELLS
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