Breast Cancer Therapeutics in Major Developed Markets Trends to 2021 2 | Page 4

2.8.4 Targeted Therapies 20
2.8.5 Resistance to Pharmacological Therapies 20
2.9 Treatment Guidelines 21
3 Marketed Products 24
3.1 Overview 24
3.1.1 Herceptin (trastuzumab) – Genentech 24
3.1.2 Perjeta (pertuzumab) – Genentech 26
3.1.3 Afinitor (everolimus) – Novartis 27
3.1.4 Tykerb/ Tyverb (lapatinib ditosylate monohydrate) – Novartis 28
3.1.5 Ibrance (palbociclib) – Pfizer 29
3.1.6 Ixempra (ixabepilone) – Bristol-Myers Squibb 29
3.1.7 Halaven (eribulin mesylate) – Eisai 30
3.1.8 Avastin (bevacizumab) – Genentech 31
3.1.9 Kadcyla (ado-trastuzumab emtansine) – Genentech 31
3.1.10 Marketed Products Heatmap 32
3.1.11 Measuring the Effectiveness of Treatment 38
3.2 Conclusion 39
4 Pipeline Products 40
4.1 Pipeline Products 40
4.1.1 Overall Pipeline 40
4.1.2 Pipeline by Molecular Target 41
4.2 Clinical Trials 44
4.2.1 Failure Rate 44
4.2.2 Patient Enrollment and Clinical Trial Size 46
4.2.3 Duration 50