Khaled Alrosan ( Create Your Thesis )
School of Pharmacy and Bioengineering
Improving the therapeutic index of navitoclax in the treatment of ovarian cancer
Ovarian cancer is considered a major health problem . The chemotherapeutic drugs that are used to treat ovarian cancer often are less effective because of the development of drug resistance . The evasion of apoptosis due to overexpression of anti-apoptotic BCL-2 family members is a major cause of this resistance . Navitoclax is a BH3 mimetic which inhibits several Bcl-2 family proteins . However , clinical success with navitoclax has been limited because it causes a decrease in platelets number . Thus , this needs strategies to target navitoclax to ovarian cancer cells and we have investigated the formulation of navitoclax in nanoparticles to achieve this .
Postgraduate Conference 2020 Page 12