He has starred alongside Bollywood superstar Shahrukh Khan many times in films such as Darr (1993), Dilwale Dulhaniya Le Jayenge (1995), Chaahat (1996), Kuch Kuch Hota Hai (1998), Mohabbatein (2000) and Veer-Zaara (2004).
In 2011, he starred alongside Mohanlal and Jayaprada in the Malayalam language romantic drama Pranayam. Kher chose Pranayam as one of the seven best films of his career..
He also starred in a number of Marathi films such as Thoda Tuza...Thoda Maza, Kashala Udyachi Baat and Punjabi films such as Yaaraan naal bahaaraan.
He is widely regarded as an intellectual talk show participant.
AWARDS AND RECOGNITION
Civilian award
2004: Padma Shri by the Government of India for his contribution to Indian cinema
National Film Awards
1989: National Film Award – Special Jury Award: Daddy
2005: National Film Award – Special Jury Award: Maine Gandhi Ko Nahin Mara
Filmfare Awards
Wins
1984: Best Actor, Saaransh
1988: Best Supporting Actor, Vijay
1989: Best Comedian, Ram Lakhan
1990: Critics Award for Best Performance, Daddy
1991: Best Comedian, Lamhe
1992: Best Comedian, Khel
1993: Best Comedian, Darr
1995: Best Comedian, Dilwale Dulhaniya Le Jayenge
Nominations
1986: nominated: Best Supporting Actor, Janam
1991: nominated: Best Supporting Actor, Dil
1992: nominated: Best Supporting Actor, Saudagar
1994: nominated: Best Supporting Actor, Hum Aapke Hain Koun..!
1997: nominated: Best Supporting Actor, Chaahat
2013: nominated: Best Supporting Actor, Special 26
Screen Awards
1994: Best Supporting Actor for 1942: A Love Story
1999: Best Comedian for Haseena Maan Jayegi
Bollywood Movie Awards
1999 : Best Supporting Actor for Salaakhen
2007 : Best Comedian for Khosla Ka Ghosla
Other awards
2000: Actor of the Decade Award (Millennium Honours)
2000: Best Actor in a Comic Role at the Sansui Viewers Choice Awards
2001: Real Life Hero Award at the Zee Gold Bollywood Awards[18]
2005: "Divya Himachal Award" for excellence 2005, with the blessings of H.H. Dalai Lama
2005: Best Actor Award from the Karachi International Film Festival for Maine Gandhi Ko Nahin Mara
2006: Best Actor Award at the Riverside International Film Festival at California for Maine Gandhi Ko Nahin Mara
2006: GIFA awards: Critics Choice Awards – Best Actor in a Comic Role for Khosla Ka Ghosla
2013: Outstanding Achievement in Cinema award at The Asian Awards.[23]