Human genes critical to immunity or inflammation also play role in HIV- 1 pathogenesis and have been of interest for genetic studies . Polymorphisms in the genes encoding cytokines , cytokine receptors have been associated with both resistance and disease progression kinases . More recently , the use of CRISPR / Cas9 genome editing approach has also confirmed host CD4 and CCR5 along with ALCAM ( responsible for cell aggregation required for cell-to-cell HIV transmission ), TPST2 and SCL35B2 ( facilitate CCR5 recognition ) to be essential for HIV infection . These new generation host genetic
approaches are critical to functionally validate genome wide studies and identify therapeutic targets to control HIV infection . In conclusion , it is detrimental to undertake large cohort studies including individuals from multiple ethnic background and integrate different layers of data generated using multiple approaches .
siRNA transfection and shRNA transduction studies , minimal overlap across studies was investigated in genes potentially necessary for optimal viral replication . These investigations emphasize the necessity to improve precision of transcriptome analysis through added resolution of RNA-Seq . However , genes identified in two or more independent transfection screens belonged to nuclear pore machinery , components of NF-kB complex and key
Dr Partha P . Majumder is a Professor of Human Genetics in the Indian Statistical Institute , Kolkata , and the founder of the National Institute of Biomedical Genomics , Kalyani , West Bengal , where he is currently a Distinguished Professor . He is also a Sir J . C . Bose National Fellow . He has pioneered the development of many statistical methods in the analysis of human genome diversity and genetic epidemiology .
Dr Ankita Garg , ANKITA GARG is an Assistant Professor at the National Institute of Biomedical Genomics , Kalyani , West Bengal . She has over 12 years of experience in translational research in the field of infectious diseases and immunology . She is recipient of various national and international awards including Young Investigator Award from IAS-USA and Global Health Travel Award by Bill and Melinda Gates Foundation .
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