expert corner
HIV-1 AND THE HOST:
A Tale of Two Genomes!
In an insightful scientific article, Dr Partha P. Majumder and Dr Ankita Garg,
National Institute of Biomedical Genomics, share their interesting perspective
on the latest research efforts to track the Human Immunodeficiency Virus (HIV-
1). Read on for details:
The clinical outcome of
HIV-1 infection ranges
from: rapid progressors,
slow progressors, long
term non-progressors
(LTNP) to individuals
remaining seronegative
despite high risk/multiple
HIV-1 exposure. This
spectrum of clinical
manifestation, along
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BioVoiceNews | April 2017
with the risk of HIV-1
acquisition, is directly
or indirectly influenced
by the genetic make-
up of the host, i.e., the
individual who is infected
or exposed.
Over the past several
years, population studies
in HIV host genetics have
unraveled a series of
human gene variants that
modulate the response
to HIV exposure. Genetic
studies have identified
genetic variants in some
chemokine receptors
CCR5, CCR2, CX3CR1,
CXCR1 and CXCR6
that are associated with
HIV-1 acquisition and