BioVoice News April 2017 Issue 11 Volume 1 | Page 36

expert corner HIV-1 AND THE HOST: A Tale of Two Genomes! In an insightful scientific article, Dr Partha P. Majumder and Dr Ankita Garg, National Institute of Biomedical Genomics, share their interesting perspective on the latest research efforts to track the Human Immunodeficiency Virus (HIV- 1). Read on for details: The clinical outcome of HIV-1 infection ranges from: rapid progressors, slow progressors, long term non-progressors (LTNP) to individuals remaining seronegative despite high risk/multiple HIV-1 exposure. This spectrum of clinical manifestation, along 36 BioVoiceNews | April 2017 with the risk of HIV-1 acquisition, is directly or indirectly influenced by the genetic make- up of the host, i.e., the individual who is infected or exposed. Over the past several years, population studies in HIV host genetics have unraveled a series of human gene variants that modulate the response to HIV exposure. Genetic studies have identified genetic variants in some chemokine receptors CCR5, CCR2, CX3CR1, CXCR1 and CXCR6 that are associated with HIV-1 acquisition and