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Dr Hayley Heaton ( left ) Infectious diseases and microbiology advanced trainee , Canberra Hospital , ACT .
Professor Peter Collignon
AM ( right ) Infectious diseases physician and microbiologist , Canberra Hospital ; professor , Australian National University medical school , ACT .
First published online on 31 March 2023
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INTRODUCTION
LYME disease , or Lyme borreliosis , is a
tick-borne disease ( see figure 1 ) caused by the spirochaetes in the Borrelia burgdorferi sensu lato complex .
Lyme disease was initially described in 1982 following the persistence of parents in Lyme , Connecticut , US , who were concerned about an epidemic of inflammatory arthritis in local children , which was initially misdiagnosed as rheumatoid arthritis . 1 This prompted an investigation by the Connecticut State Health Department and ultimately led to characterisation of the disease .
B . burgdorferi sensu lato ( sl ) is known to be endemic in North America and Europe , with increasing reports of Lyme disease in Asia . In Australia , though , there is no evidence of locally acquired classical Lyme disease or that the causative bacteria ( B . burgdorferi sl ), or closely related forms , exist in Australia .
The natural course of B . burgdorferi sl infection varies greatly and has three distinct clinical stages : early , disseminated and late . The classical early clinical manifestations of Lyme disease usually include fever , characteristic erythema migrans rash and
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Figure 1 . Infected female deer tick on human skin .
lymphadenopathy . However , once disseminated to other organs or tissues , there can be a wide range of manifestations , such as arthritis , meningitis or carditis . Early antibiotic treatment
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of Lyme disease usually leads to full recovery , but antibiotic treatment of late-stage Lyme disease is associated with more variable degrees of recovery . |
The prompt diagnosis of Lyme disease usually relies on appropriate epidemiological risk factors for acquisition of B . burgdorferi sl infection , corresponding clinical |