RECENT RESEARCH
mechanisms, including an increase in the dietary intake of antioxidant elements, have been postulated to underlie this phenomenon. Because of its anti-oxidative qualities, anti-inflammatory effects, impact on endothelial nitric oxide synthase, improvement of endothelial function, modulation of vascular smooth muscle activity, and reduction of arterial stiffness, CoQ10 has been suggested as a possible alternative therapy for hypertension and related complications. Clinical trials have produced findings that suggest CoQ10 supplementation may lower both systolic and diastolic blood pressure in individuals diagnosed with essential hypertension, frequently as a component of adjunctive therapy. Nonetheless, a thorough comprehension of the mechanisms that determine the effects of CoQ10 on blood pressure and its related complications continues to be elusive. This narrative review investigates the mechanistic effects of CoQ10 on hypertension and its accompanying consequences, with an emphasis on its pharmacological impact on inflammation and oxidative-related pathways. We have conducted an exhaustive literature search, identifying several studies that assess the safety and effectiveness of CoQ10 supplementation in hypertensive patients. Reid IR. Calcium / Vitamin D Supplements and the Heart. Trends Cardiovasc Med. 2025 Aug 13: S1050- 1738( 25) 00109-4. doi: 10.1016 / j. tcm. 2025.08.005. Epub ahead of print. PMID: 40816635.
Ebrahimi Daryani N, Alebouyeh M, Tajeddin E, Nazarbeigi S, Jaafari MR, Elyasi S, Karbasforooshan H, Akhondzadeh Basti S, Abdollahi A, Aletaha N, Miri R, Moosavian M.
Evaluation of oral nano-curcumin formulation effectiveness in patients with mild to moderate ulcerative colitis: a randomized, placebo-controlled, doubleblind clinical trial. Naunyn Schmiedebergs Arch Pharmacol. 2025. doi: 10.1007 / s00210-025-04484-2. Epub ahead of print. PMID: 40820062.
Recent clinical trials have exhibited that curcumin, a natural polyphenolic compound, is effective as adjuvant therapy in patients with ulcerative colitis( UC).
In this randomized, placebo-controlled, double-blind study, 43 patients with mildmoderate UC who were referred to the gastrointestinal ward of Imam Khomeini Hospital in Tehran, Iran were assessed. They were randomly specified to the intervention( n = 21, SinaCurcumin ® soft gel 80 mg) or the placebo( n = 22) group, administered twice a day for 1 month, in addition to 5-aminosalicylic acid. The main consequence of the study was to get to a decrement of at least three scores in the Simple Clinical Colitis Activity Index( SCCAI) within a month. Endoscopic and histopathological responses and Hospital Anxiety and Depression Scale( HADS) score changes were also recorded. The clinical( p = 0.031, χ2 = 4.66) and endoscopic( p = 0.005, χ2 = 8.55) responses and also HADS score changes( p = 0.06, t =- 1.35) were significantly higher in the treatment group. No significant diversity was presented between groups in terms of inflammatory markers and total anti-oxidant capacity and fecal calprotectin level( p value > 0.05). Nanocurcumin oral formulation with a dose of 80 mg twice daily for 1 month in patients with mild to moderate UC could be an effective adjunct to 5-aminosalicylic acid in clinical, endoscopic, and histopathological response.
Li R, Li M, Wang X, Zhou Z. Oxidative stress and inflammation link Life’ s Essential 8 with adverse cardiovascular events in adults with diabetes mellitus: NHANES 2011-2018. Clin Investig Arterioscler. 2025: 500844. English, Spanish. doi: 10.1016 / j. arteri. 2025.500844. Epub ahead of print. PMID: 40819958.
Background: The American Heart Association has modified Life’ s Essential 8( LE8) as a new algorithm for evaluating cardiovascular health( CVH). However, the relationship between LE8 and cardiovascular disease( CVD) incidence among diabetic patients, and the potential effect of oxidative stress and inflammation within these associations remain to be elucidated.
Methods: Three thousand eight hundred twenty-eight diabetic patients were selected from the National Health and Nutrition Examination Survey( NHANES). The weighted logistic regression was employed to examine the association between LE8 with CVD, and the quantitative relationship was investigated with a restricted cubic spline( RCS). Mediation analyses explored the mediating role of oxidative stress and inflammation in the above relationship.
Results: In the 3828 diabetic patients, a total of 977 people were diagnosed with CVD, and the LE8 was significantly and linearly negatively associated with CVD incidence. After all covariates were adjusted, the medium CVH group had a 25 % lower risk of CVD( OR: 0.75, 95 % CI: 0.58, 0.95) than the low CVH group, and the high CVH group had a 66 % lower risk( OR: 0.34, 95 % CI: 0.12, 0.94). Furthermore, oxidative stress and inflammation explained 11.57 % and 10.89 % of the connection, respectively( P < 0.05).
Conclusion: Elevated LE8 is negatively associated with adverse cardiovascular events in diabetes mellitus and the association appeared to be partially mediated through oxidative stress and inflammation pathways. Those results indicate the necessity of maintaining at least moderate cardiovascular health and the LE8 help make lifestyle selfmanagement more targeted for diabetes patients.
Reid IR. Calcium / Vitamin D Supplements and the Heart. Trends Cardiovasc Med. 2025: S1050- 1738( 25) 00109-4. doi: 10.1016 / j. tcm. 2025.08.005. PMID: 40816635.
In summary, calcium supplements have been shown to have no clinically significant effect on fracture risk, carry significant adverse effects on gastrointestinal symptoms and renal calculi, and possibly adversely impact on cardiovascular disease. Therefore, there is little reason to use them in the management of osteoporosis, and cardiologists could play an important role in discouraging their inappropriate use. In contrast, physiological supplements of vitamin D restore normal vitamin D levels in those who are sunlight deprived, at very low cost and with no discernible adverse effects. Their targeted use in those without adequate sunlight exposure should be encouraged.
184 | vol31 | no3 | JATMS