August 2019 Issue #32 August 2019 Issue #32 | Page 155

There are several key messages that can be given to clients about the risk of HIV transmission through anal sex (where the HIV-negative person inserts their penis into an HIV-positive partner’s anus): - Rectal fluid can contain a high concentration of HIV and, if it comes into contact with a partner’s penis, can lead to HIV transmission. - HIV transmission through this type of anal sex does not require blood to be present in the HIV-positive partner’s rectum. - Inflammation in the rectum, caused by STIs or tearing, may in- crease the amount of virus in the rectal fluid and increase the risk of HIV transmission. Minimizing rectal inflammation through the use of lubricants (lubes) and management of STIs (regular STI testing and, if needed, treatment for STIs) may prevent increases in rectal fluid viral load. - Lowering the viral load in the blood and rectal fluid through success- ful antiretroviral treatment can substantially decrease the risk of HIV transmission. - Condoms, in combination with lube, are highly effective in prevent- ing the risk of HIV transmission if used consistently and correctly. Condoms can also significantly reduce the risk of STI transmission. - Post-exposure prophylaxis and pre-exposure prophylaxis are both highly effective options for HIV-negative people to reduce their risk of HIV infection. PEP needs to be accessed as soon as possible, but within 72 hours, after an exposure and taken daily for 28 days. PrEP needs to be taken daily, on an ongoing basis. Adherence to daily pill-taking is important for both to be effective. - Penile circumcision may reduce the risk of HIV infection for HIV-negative gay men who primarily engage in insertive anal sex, but it is unclear how much it reduces HIV transmission risk. 155