ATMS Journal Winter 2025 (Public Version) | Page 18

dietary and lifestyle modifications offer effective strategies for reducing inflammation. The growing body of scientific literature supports the use of Buglossoides arvensis( Ahiflower, Corn Gromwell) as an extremely beneficial therapeutic adjunct.
Financial disclosure: Camilla co-founded PhytoLove, a company with exclusive distribution rights to Buglossoides arvensis seed oil in Australia and New Zealand.
REFERENCES
1. Medzhitov R. Origin and physiological roles of inflammation. Nature. 2008; 454( 7203): 428-35.
2. Hotamisligil GS. Inflammation, metaflammation and immunometabolic disorders. Nature. 2017; 542( 7640): 177-85.
3. Fullerton JN, Gilroy DW. Resolution of inflammation: a new therapeutic frontier. Nat Rev Drug Discov. 2016; 15( 8): 551-67.
4. Calder PC. Omega-3 fatty acids and inflammatory processes: from molecules to man. Biochem Soc Trans. 2017; 45( 5): 1105- 15.
5. Furman D, Campisi J, Verdin E, Carrera- Bastos P, Targ S, Franceschi C, et al. Chronic inflammation in the etiology of disease across the life span. Nature Medicine. 2019; 25( 12): 1822-32.
6. Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med. 2000; 342( 12): 836-43.
7. Esteve E, Castro A, López-Bermejo A, Vendrell J, Ricart W, Fernández-Real J-M. Serum Interleukin-6 Correlates With Endothelial Dysfunction in Healthy Men Independently of Insulin Sensitivity. Diabetes Care. 2007; 30( 4): 939-45. 8. Brennan FM, McInnes IB. Evidence that cytokines play a role in rheumatoid arthritis. J Clin Invest. 2008; 118( 11): 3537-45.
9. Seidel U, Eberhardt K, Wiebel M, Luersen K, Ipharraguerre IR, Haegele FA, et al. Stearidonic acid improves eicosapentaenoic acid status: studies in humans and cultured hepatocytes. Front Nutr. 2024; 11:1359958.
10. Lefort N, LeBlanc R, Surette ME. Dietary Buglossoides Arvensis Oil Increases
Circulating n-3 Polyunsaturated Fatty Acids in a Dose-Dependent Manner and Enhances Lipopolysaccharide-Stimulated Whole Blood Interleukin-10-A Randomized Placebo-Controlled Trial. Nutrients. 2017; 9( 3).
11. Lefort N, LeBlanc R, Giroux MA, Surette ME. Consumption of Buglossoides arvensis seed oil is safe and increases tissue longchain n-3 fatty acid content more than flax seed oil- results of a phase I randomised clinical trial. J Nutr Sci. 2016; 5: e2.
12. Laevski AM, Doucet MR, Doucet MS, LeBlanc AA, Pineau PE, Hébert MPA, et al. Dietary omega-3 fatty acids modulate the production of platelet-derived microvesicles in an in vivo inflammatory arthritis model. Eur J Nutr. 2024; 63( 6): 2221-34.
13. Scalbert A, Johnson IT, Saltmarsh M. Polyphenols: antioxidants and beyond. Am J Clin Nutr. 2005; 81( 1 Suppl): 215s-7s.
14. Grosso G, Stepaniak U, Micek A, Stefler D, Bobak M, Pająk A. Dietary polyphenols are inversely associated with metabolic syndrome in Polish adults of the HAPIEE study. Eur J Nutr. 2017; 56( 4): 1409-20.
15. Hussain T, Tan B, Yin Y, Blachier F, Tossou MC, Rahu N. Oxidative Stress and Inflammation: What Polyphenols Can Do for Us? Oxid Med Cell Longev. 2016; 2016:7432797.
16. McMacken M, Shah S. A plant-based diet for the prevention and treatment of type 2 diabetes. J Geriatr Cardiol. 2017; 14( 5): 342-54.
17. Craddock JC, Neale EP, Peoples GE, Probst YC. Vegetarian-Based Dietary Patterns and their Relation with Inflammatory and Immune Biomarkers: A Systematic Review and Meta-Analysis. Adv Nutr. 2019; 10( 3): 433-51.
18. Goldner B, Staffier KL. Case series: raw, whole, plant-based nutrition protocol rapidly reverses symptoms in three women with systemic lupus erythematosus and Sjögren’ s syndrome. Frontiers in Nutrition. 2024; 11.
19. Makki K, Deehan EC, Walter J, Bäckhed F. The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease. Cell Host Microbe. 2018; 23( 6): 705-15.
20. Vitaglione P, Mennella I, Ferracane R, Rivellese AA, Giacco R, Ercolini D, et al. Whole-grain wheat consumption reduces inflammation in a randomized controlled trial on overweight and obese subjects with unhealthy dietary and lifestyle behaviors: role of polyphenols bound to cereal dietary fiber234. The American Journal of Clinical Nutrition. 2015; 101( 2): 251-61.
21. Snauwaert E, Paglialonga F, Walle J, Wan M, Desloovere A, Polderman N, et al. The benefits of dietary fiber: the gastrointestinal tract and beyond. Pediatric Nephrology. 2022; 38.
22. Irwin MR, Olmstead R, Carroll JE. Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation. Biol Psychiatry. 2016; 80( 1): 40-52.
23. Besedovsky L, Lange T, Haack M. The Sleep- Immune Crosstalk in Health and Disease. Physiol Rev. 2019; 99( 3): 1325-80.
24. Prather AA, Janicki-Deverts D, Hall MH, Cohen S. Behaviorally Assessed Sleep and Susceptibility to the Common Cold. Sleep. 2015; 38( 9): 1353-9.
25. Gleeson M, Bishop NC, Stensel DJ, Lindley MR, Mastana SS, Nimmo MA. The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol. 2011; 11( 9): 607-15.
26. Scheffer DDL, Latini A. Exercise-induced immune system response: Antiinflammatory status on peripheral and central organs. Biochim Biophys Acta Mol Basis Dis. 2020; 1866( 10): 165823.
27. Woods JA, Wilund KR, Martin SA, Kistler BM. Exercise, inflammation and aging. Aging Dis. 2012; 3( 1): 130-40.
28. Nieman DC, Wentz LM. The compelling link between physical activity and the body ' s defense system. J Sport Health Sci. 2019; 8( 3): 201-17.
29. Slavich GM, Irwin MR. From stress to inflammation and major depressive disorder: a social signal transduction theory of depression. Psychol Bull. 2014; 140( 3): 774- 815.
30. Uchino BN, Trettevik R, Kent de Grey RG, Cronan S, Hogan J, Baucom BRW. Social support, social integration, and inflammatory cytokines: A meta-analysis. Health Psychol. 2018; 37( 5): 462-71.
31. Robles TF. Annual Research Review: Social relationships and the immune system during development. Journal of Child Psychology and Psychiatry. 2021; 62( 5): 539- 59.
78 | vol31 | no2 | JATMS