1 month. 28 Pyridoxine hydrochloride supplementation led to a decrease in self-reported anxiety levels and suggested a potential reduction in depressive symptoms. 28
Vitamin B6 and Inflammation Inflammation-related diseases, such as cardiovascular disease, diabetes, rheumatoid arthritis, and inflammatory bowel disease have been associated with low vitamin B6 status. 10 Vitamin B6 plays a role in reducing inflammation by modulating the function and activity of inflammasomes, particularly the nucleotide-binding domain, leucinerich-containing family, pyrin domaincontaining-3( NLRP3) sensory protein. 9 Research indicates a negative correlation between vitamin B6 intake and inflammation levels. 32 Additionally, research indicates that individuals with chronic inflammation exhibited the lowest levels of vitamin B6, while those with elevated vitamin B6 levels demonstrated reduced inflammation. 9 Individuals with insufficient vitamin B6 demonstrate elevated inflammatory markers. 32 The impact of inflammation on vitamin B6 levels may result from the accumulation of PLP in inflamed tissues, 10, 32 potentially being attracted to areas of active inflammation 32 and / or from heightened metabolic breakdown. 10
PLP reduces the synthesis of IL-1β, a strong proinflammatory cytokine, as well as reducing the generation of reactive oxygen species( ROS) by inhibiting the NLRP3 inflammasome. 9 A deficiency in Vitamin B6 can lead to elevated levels of IL-1β and subsequent tissue damage caused by free radicals. 9 Vitamin B6 is involved in the action of the transcription factor NF-κB. 9 There is an inverse relationship between vitamin B6 and IL-6 and TNF-α levels in conditions of chronic inflammation. 9, 33 Vitamin B6 supplementation decreased IL-6 levels in patients with chronic disease 9 and rheumatoid arthritis. 33
Vitamin B6 promotes the phosphorylation of adenosine monophosphate-activated protein kinase( AMPK) at the Thr172 site, which enhances its activity. This kinase acts as an inhibitor of inflammatory processes within the cell. 9 Vitamin B6 plays a role in the regulation of anserine, carnosine, histamine, and GABA, and it may also influence the P2X7R – NLRP3 inflammasome, which could contribute to the reduction of inflammation. 9
PLP plays a crucial role in the conversion of sphingosine-1-phosphate. 9 Sphingosine-1- phosphate serves as a potent inflammatory mediator and is instrumental in facilitating the release of lymphocytes from lymphoid tissues. This molecule acts as a regulatory factor in the development of cells within both the hematopoietic and nervous systems. 9 Often referred to as a director or conductor among cellular components, sphingosine-1- phosphate significantly influences their differentiation, migration, adhesion, and overall lifespan. 9 In the case of PLP deficiency, the activity of sphingosine-1- phosphate lyase is suppressed. 9 A deficiency in sphingosine-1-phosphate lyase results in the accumulation of lymphocytes within secondary lymphatic organs and areas of inflammation. 9 This condition contributes to lymphopenia and immunosuppression, aggravates local inflammatory responses and elevates the production of proinflammatory cytokines. 9
Vitamin B6 and Oxidative Stress Vitamin B6 is a key player in the antioxidant system 32 and has antioxidant properties. 8 While vitamin B6 is not traditionally recognised as a classical antioxidant, it has the ability to neutralise reactive oxygen species( ROS) and inhibit the development of advanced glycation end products( AGEs). 16 PLP-dependent enzymes are believed to function directly as a defensive mechanism against reactive oxygen species, including singlet oxygen. 7
Flourish- Reigniting the Art & Science of Innate Healing Throughout the Lifespan
Saturday 16 & Sunday 17 August 2025 Sofitel Brisbane Central or via Live Stream For practitioners only.
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DISCOVER The latest findings on post-traumatic growth and emotional resilience.
EXPLORE The potent anti-inflammatory and detoxification pathways within us.
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