RECENT RESEARCH
treatment of precursor human papilloma virus ( HPV ) conditions does not exist . The Centers for Disease Control and Prevention ( CDC ) estimates 36,500 new cases of ( HPV ) -associated cancers per year . The purpose of this report is to illustrate a method that could eliminate HPV positivity to control precancerous lesions before they develop carcinoma . Eighty-six percent of cervical cancers contain HPV as a likely causal factor .
Design / Setting : Two patients sought private practice integrative medicine : one for chronic HPV-induced cervical dysplasia , the other with lichen sclerosis post squamous cell carcinoma ( SCC ).
Methods : The two patients were included because they asked for help with their conditions , since no previous medical help was either offered or successful . Patients were treated with a systematic integrative approach , designed to normalize leaky gut , and microbiome to reduce systemic antigenic stimulation . Also , berberine and curcumin were given , based on in vitro data on their effectiveness for treating HPV-induced oncogenic changes in cells . Those herbal derivatives were obtained from an organic chemist who maintained strict quality control .
Results : A patient with oncogenic HPVinduced chronic severe cervical dysplasia had a dramatic improvement of dysplasia and HPV positivity . The patient with lichen sclerosis and atrophicus had a 75 % improvement in the appearance of her condition , and her suspected SCC was in situ .
Discussion : From this limited case report , it appears that a combination of integrative methods , plus curcumin and berberine , can clear oncogenic HPV and reverse dysplastic and oncogenic changes in the cervix as well as autoimmune changes in the vaginal area .
Conclusion : The combination of integrative methods and curcumin and berberine helped patients with oncogenic HPV-induced cervical dysplasia and autoimmune and cancer-forming lichen sclerosis . Considering the high prevalence of HPV-induced cervical dysplasia , and the lack of treatment , this study should be repeated at a larger level .
Tayeb BA , Kusuma IY , Osman AAM , Minorics R . Herbal compounds as promising therapeutic agents in precision medicine strategies for cancer : A systematic review . J Integr Med . 2024 ; 22 ( 2 ): 137-162 . doi : 10.1016 / j . joim . 2024.02.001
Background : The field of personalized medicine has gained increasing attention in cancer care , with the aim of tailoring treatment strategies to individual patients for improved outcomes . Herbal medicine , with its long-standing historical use and extensive bioactive compounds , offers a rich source of potential treatments for various diseases , including cancer .
Objective : To provide an overview of the current knowledge and evidence associated with incorporating herbal compounds into precision medicine strategies for cancer diseases . Additionally , to explore the general characteristics of the studies included in the analysis , focusing on their key features and trends .
Search strategy : A comprehensive literature search was conducted from multiple online databases , including PubMed , Scopus , Web of Science , and CINAHL-EBSCO . The search strategy was designed to identify studies related to personalized cancer medicine and herbal interventions .
Inclusion criteria : Publications pertaining to cancer research conducted through in vitro , in vivo , and clinical studies , employing natural products were included in this review .
Data extraction and analysis : Two review authors independently applied inclusion and inclusion criteria , data extraction , and assessments of methodological quality . The quality assessment and biases of the studies were evaluated based on modified Jadad scales . A detailed quantitative summary of the included studies is presented , providing a comprehensive description of their key features and findings .
Results : A total of 121 studies were included in this review for analysis . Some of them were considered as comprehensive experimental investigations both in vitro and in vivo . The majority ( n = 85 ) of the studies included in this review were conducted in vitro , with 44 of them specifically investigating the effects of herbal medicine on animal models . Additionally , 7 articles with a combined sample size of 31,271 patients , examined the impact of herbal medicine in clinical settings .
Conclusion : Personalized medication can optimize the use of herbal medicine in cancer treatment by considering individual patient factors such as genetics , medical history , and other treatments . Additionally , active phytochemicals found in herbs have shown potential for inhibiting cancer cell growth and inducing apoptosis , making them a promising area of research in preclinical and clinical investigations .
Yujie Z , Kaoqiang L , Yunfan Z , Ye Z , Yongli C , Jiawei N , Hui P , Lingjun K , Wei ' an Y . Impact of Chinese herbal medicine on sarcopenia in enhancing muscle mass , strength , and function : A systematic review and meta-analysis of randomized controlled trials . Phytother Res . 2024 ; 38 ( 5 ): 2303-2322 . doi : 10.1002 / ptr . 8154
Sarcopenia has become important to the public health with the increase in the aging population in society . However , the therapeutic effects of conventional approaches , including pharmacotherapy , exercise , and nutritional intervention , are far from satisfactory . Chinese herbal medicine is a new treatment format with interesting possibilities in sarcopenia has been widely practiced . The study aimed to explore the effectiveness of Chinese herbal medicine in sarcopenia . We comprehensively searched the following electronic databases : Medline , EMBASE , APA PsycInfo , Cochrane Library , Web of Science , PubMed , and Chinese database from the establishment of the database to December 2022 ( no language restrictions ). Randomized controlled clinical studies on the use of Chinese herbal medicine in sarcopenia were selected in compliance with PRISMA guidelines . Review Manager and Stata were used for statistical analysis and the mean difference and
110 | vol30 | no2 | JATMS