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‘ Chanzymes ’: Cell membrane channel gatekeepers ( TRPM7 ) that are sensitive to magnesium
The enzyme protein channels in the cell membrane that open and close , facilitating the transcellular movement of magnesium , are now referred to as ‘ chanzymes ’. They are sensitive to the presence of magnesium when it comes knocking , and are associated with the resting state . When magnesium becomes depleted , or adrenalin pushes in more calcium which overtakes magnesium , the channels switch to the tension , or ‘ squeezed ’, state of contraction .
Interestingly , if you can get enough magnesium uptake it can control the excess calcium of hypercalcaemia . Without enough magnesium , calcium becomes the bully with brute force – stiffening , hardening and cramping muscles ( including the smooth muscles in the endothelial linings of blood vessels ).
Researchers confirm that “ intracellular Mg2 + binds to this site and stabilizes the TRPM7 channel in the closed state , whereas the removal of Mg2 + favours the opening of TRPM7 . Hence , our study identifies the structural underpinnings through which the TRPM7 channel is controlled by cytosolic Mg2 +, representing a new structure-function relationship .” 3 Another study found that “ TRPM7 is essential for the control of cellular and whole body Mg2 + homeostasis .” 4
What happens when optimal magnesium is available and the body is in a calm state is that the cell membrane ( via TRPM7 ) maintains its electrical charge potential to hold in the magnesium and potassium ion . When there is a stress response and adrenalin is released , it pulls out magnesium and pushes calcium into the cell membrane channels of muscle fibres , which has a dehydrating and tightening effect for quick action of the muscles and cardiovascular system .
When calm is restored , calcium is once again moved out of the membrane channels , allowing magnesium back in for relaxation of the muscle . As magnesium brings water molecules with it , it increases hydration inside the cell , consequently relaxing and restoring internal cell transport ( nutrients in and wastes out ). Magnesium also donates electrons , which assists the antioxidant system to neutralise free radicals .
I am convinced that transdermal magnesium saved me from debilitating symptoms of hypothyroidism and heart arrhythmia , and helped me breeze through menopause without the stress , hot flushes or sleeplessness commonly reported by women in menopause . It has rejuvenated my energy levels , muscles and skin complexion with amazing anti-ageing results and I now understand why many researchers have referred to magnesium as the ‘ fountain of youth ’. Getting more magnesium in via skin is easier than you may realise . Try it and feel the difference .
REFERENCES :
( 1 ) Schuchardt JP , Hahn A . Intestinal absorption and factors influencing bioavailability of magnesium : An update . Curr Nutr Food Sci , 2017 ; 13 ( 4 ): 260 – 278 . https :// doi . org / 10.2174 / 15734013136661704 27162740 .
( 2 ) Chandrasekaran N . Effect of topical magnesium application on epidermal integrity and barrier function . The University of Queensland , 2016 .
( 3 ) Schmidt E , Narangoda C , Nörenberg W , Egawa M , Rössig A , Leonhardt M , Schaefer M , Zierler S , Kurnikova MG , Gudermann T , Chubanov V . Structural mechanism of TRPM7 channel regulation by intracellular magnesium . Cell Mol Life Sci , 2022 ; 79 ( 5 ): 225 . https :// doi . org / 10.1007 / s00018-022-04192-7 .
( 4 ) Ryazanova LV , Rondon LJ , Zierler S , Hu Z , Galli J , Yamaguchi TP , Mazur A , Fleig A , Ryazanov AG . TRPM7 is essential for Mg2 + homeostasis in mammals . Nat Commun , 2010 ; 1 ( 1 ): 109 . https :// doi . org / 10.1038 / ncomms1108
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