RECENT RESEARCH
13 studies passed and were selected for modeling . Mild AEs were the most frequent , accounting for n = 161 / 165 ( 98 %) of total AEs observed in the literature . The cumulative incidence of mild AEs was also significantly greater ( P = 0.01 ) than both moderate and severe grades . The benchmark incidence rate was 1.0 AEs per 100 post-OMT interval-days .
Conclusions : The majority of post-OMT AEs observed in the primary clinical literature were of mild severity . Modeling of the combined dataset on post-OMT AEs allowed for the derivation of a patient safety benchmark that , to date , has not been established in the field of osteopathic manipulative medicine . Additional research is needed to improve model resolution during the post-OMT period . This work conceptualized a model for identifying and grading post-OMT AEs , which should facilitate future comparisons between institutions in order to continually improve patient safety standards in the field of osteopathic manipulative medicine .
Cupler ZA , Gliedt JA , Perle SM et al . Associations between demographics and clinical ideology , beliefs , and practice patterns : a secondary analysis of a survey of randomly sampled United States chiropractors . BMC Complement Med Ther . 2023 ; 23 , 404 . https :// doi . org / 10.1186 / s12906-023-04225-z
Background : The chiropractic profession in the United States ( US ) has a long history of intra-professional discourse surrounding ideology and beliefs . Large-scale efforts have evaluated 3 distinctive subgroups of US chiropractors focused on these areas of practice : spine / neuromusculoskeletal , primary care , and vertebral subluxation . To our knowledge , there have not been any prior studies exploring the factors associated with these ideology and belief characteristics of these subgroups . The purpose of this study was to explore , describe , and characterize the association of US chiropractors ’ ideology , beliefs , and practice patterns with : 1 ) chiropractic degree program of graduation , 2 ) years since completion of chiropractic degree , and 3 ) US geographic region of primary practice .
Methods : This was a secondary analysis of a cross-sectional survey of a random sample of US licensed chiropractors ( n = 8975 ). A 10 % random sample was extracted from each of the 50 states and District of Columbia chiropractic regulatory board lists . The survey was conducted between March 2018-January 2020 . The survey instrument consisted of 7 items that were developed to elicit these differentiating ideologies , beliefs , and practice patterns : 1 ) clinical examination / assessment , 2 ) health conditions treated , 3 ) role of chiropractors in the healthcare system , 4 ) the impact of chiropractic adjustments [ spinal manipulation ] in treating patients with cancer , 5 ) vaccination attitudes , 6 ) detection of subluxation on x-ray , and 7 ) x-ray utilization rates . Multinomial regression was used to analyze associations between these 7 ideology and practice characteristic items from the survey ( dependent variables ) and the 3 demographic items listed above ( independent variables ).
Results : Data from 3538 respondents ( 74.6 % male ) were collected with an overall response rate of 39.4 %. Patterns of responses to the 7 survey items for ideologies , beliefs , and practice characteristics were significantly different based on chiropractic degree program of graduation , years since completion of chiropractic degree , and geographic region of primary practice .
Conclusions : Among US chiropractors , chiropractic program of graduation , years since completion of chiropractic degree , and geographic region of primary practice are associated with variations in clinical ideology , beliefs , and practice patterns . The wide variation and inconsistent beliefs of US chiropractors could result in public confusion and impede interprofessional integration .
Naturopathy
Karimi F . Azadi A , Omidifar N et al . Pharmacotechnical aspects of a stable probiotic formulation toward multidrug-resistance antibacterial activity : design and quality control . BMC Complement Med Ther . 2023 ; 23 , 391 . https :// doi . org / 10.1186 / s12906-023-04224-0
As a well-known group of the probiotic family , the Lactobacillus has increasingly contributed to hindering the growth of pathogens , particularly resistant species , in the last decades . Since antibiotic resistance has become a severe problem in global healthcare systems and considerably increased the mortality and morbidity rate in infectious diseases , we aimed to obtain a new stable formulation of Lactobacillus to overcome resistant infections . For this purpose , we designed various gel formulations containing Lactobacillus rhamnosus ( L . rhamnosus ) as an active pharmaceutical ingredient ( API ) in a water base and oil base gel , evaluated the probiotic stability in formulation to obtain an optimum formulation , and finally , investigated the antibacterial activities of that against two common hospital-associated multidrugresistant pathogens , methicillin-resistant Staphylococcus aureus ( MRSA ) and vancomycin-resistant Enterococcus ( VRE ). Furthermore , the pharmaceutical aspects of the optimum formulation , including stability , homogeneity , spreadability , pH value , conductivity , and rheological behavior , were assessed . The results indicated that the optimum formulation based on glycerol exhibited desirable pharmaceutical properties , including long-term stability , a perfect level of homogeneity , an acceptable range of spreadability with pseudo-plastic thixotropic behavior , and a promising antibacterial potential against MRSA and VRE . Our findings indicate that this novel probiotic formulation could be an excellent candidate to cope with antibiotic-resistant species , representing a hopeful treatment potential for topical applications , particularly in incurable infections . However , further in vivo studies seem warranted to evaluate their bactericidal activity against multi-drug resistant microorganisms
Wolf M , Emberger-Klein A , Menrad K . Usage of Natural Health Products ( NHPs ) for respiratory diseases : user characteristics and NHP- Consumption behavior during the Covid-19 pandemic in Germany . BMC Complement Med Ther . 2023 : 23 , 372 . https :// doi . org / 10.1186 / s12906-023-04180-9
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