RECENT RESEARCH
Results : UPLC-QqQ-MS / MS analysis designated 133 chromatographic peaks with saponins , flavonoids , chalcones and pterocarpans being the most abundant groups . Triterpene saponins dominated the secondary metabolites in the aqueous extracts , with fermented samples showing the highest relative amounts . Meanwhile the ethanol extracts showed significant amounts of chalcones . Melanoidins were only detected in roasted and honey roasted samples . Multivariate models indicated that roasting of samples induced a greater effect on the polar metabolites rather than nonpolar ones . Variable of importance ( VIP ) plot indicated that glycyrrhizin and its hydrolysis product glycyrrhetinic acid , trihdroxychalcone diglycoside , glabrone and glabridin are the main chemical features responsible for the discrimination of samples .
Conclusion : Coupling UPLC-MS / MS to multivariate analysis was a successful tool that unveiled the significant effect of different pre-processing methods on the chemical profile of processed and unprocessed licorice samples . Moreover , such coupling unraveled the discriminatory chemical compounds among tested samples that can be employed as markers for the processing procedure of licorice .
Kuppusamy KM , Selvaraj S , Singaravelu P et al . Anti-microbial and anti-cancer efficacy of acetone extract of Rosa chinensis against resistant strain and lung cancer cell line . BMC Complement Med Ther . 2023 ; 23 , 406 . https :// doi . org / 10.1186 / s12906-023-04222-2
Background : Screening of herbal plants for various therapeutic properties is the hour as it shows promising activity . Scientific evidence of the pharmacological activity of the plant strengthens the traditional application of plants .
Methods : Rose flowers ( Rosa chinensis ) were procured and grounded into a coarse powder . The DNA was isolated from rose flower and molecular identification was performed by rbcL-BF and rbcL- 724R primers . Antibacterial activity was evaluated by using disc and agar diffusion methods and the anti-cancer effect of the rose flower extract ( RE ) was examined using MTT assay in lung cancer cell line . The mechanism of cell death induced by RE was qualitatively measured using Acridine orange / Ethidium bromide staining and Hoechst staining . GC-MS analysis was performed using GC-MS- 5975C .
Result : The RE showed potent antimicrobial activity against various ATCC cultures . The rose extract strongly inhibits the growth of ESBL resistant organism along with inhibition of biofilm formation in the ESBL resistant organism . The extract caused apoptotic and necrotic cell death in lung cancer cells . GC-MS analysis demonstrated the presence of several biologically active compounds such as Clindamycin , Phytol , Octanoic acid , and Stigmasterol which might be the reason for the therapeutic properties of the plant .
Conclusion : This study shows the antimicrobial and biofilm inhibition activity against the clinical isolates of Klebsiella pneumonia . The study shows the cytotoxic and apoptotic activity in A549 cancer cell line . Thus , the plant may act as a potent antimicrobial drug against resistant strains .
Krüerke D , Schenker M , Matter-Walstra K . Clinical characteristics and therapeutic behavior of breast cancer patients using mistletoe therapy consulting a clinic offering integrative oncology : A registry data analysis . BMC Complement Med Ther . 2023 ; 23 , 395 . https :// doi . org / 10.1186 / s12906-023-04219-x
Motivation : Cancer patients often use complementary and / or alternative medicine , such as mistletoe therapy , alongside conventional cancer therapies . In Switzerland , so far not much is known about treatment patterns of breast cancer patients using integrative oncology . Solid knowledge on complementary care utilization may help to enhance integrative oncology care in Switzerland .
Methods : In this exploratory , descriptive database study , we investigated the treatment pathways of a cohort of breast cancer patients who received mistletoe therapy and were documented in the cancer registry of an anthroposophic Swiss hospital offering integrative oncology treatments .
Results : Patients treated with mistletoe in this cohort are in median 10 years younger than Swiss breast cancer patients as a whole . Only 5.8 % of these patients were treated with mistletoe alone , while 60.5 % of them supplemented chemotherapy and / or hormone therapy and / or surgery and / or radiation with mistletoe therapy . Nearly 80 % of patients started conventional therapy followed by additional mistletoe therapy or started mono mistletoe therapy after completion of conventional therapies . The median time from initial diagnosis to hospital admission ( inpatient and / or outpatient ) was less than one year . Almost ¾ of the patients were treated in an outpatient setting only .
Conclusion : From our data , it appears that younger breast cancer patients are more likely to use mistletoe therapy simultaneously with or following their conventional medical therapies . The extent to which these patients discuss their mistletoe therapy and eventually other complementary and / or alternative therapies with their primary oncologists is not clear from the data . We therefore recommend that ( Swiss ) oncologists should openly discuss the desire for integrative oncology therapies , especially with their younger breast cancer patients , in order to find the best holistic care pattern for these patients .
Foshati S , Poursadeghfard M , Heidari Z et al . The effects of ginger supplementation on common gastrointestinal symptoms in patients with relapsing-remitting multiple sclerosis : a doubleblind randomized placebo-controlled trial . BMC Complement Med Ther . 2023 ; 23 , 383 . https :// doi . org / 10.1186 / s12906-023-04227-x
Background : Gastrointestinal ( GI ) symptoms affect more than 80 % of individuals with relapsing-remitting multiple sclerosis ( RRMS ). Ginger is widely known for its GI relieving properties . Therefore , we investigated the effect of ginger supplementation on common GI symptoms in RRMS patients .
234 | vol29 | no4 | JATMS