RECENT RESEARCH aqueous extracts ranged from 25-50 and 25-100 mg / ml , respectively . Rose oil at all administered doses failed to show any antibacterial activity .
Conclusion : All extracts and oil concentrations showed some degree of growth inhibition activity on T . vaginalis ; however , hydroalcoholic extract was more efficient .
Nasiri M , Torkaman M , Feizi S , Bigdeli Shamloo MB .
Effect of aromatherapy with Damask rose on alleviating adults ' acute pain severity : A systematic review and meta-analysis of randomized controlled trials . Complementary Therapies in Medicine , 2021 ; 56
Background and purpose : Although recent studies have investigated the analgesic activity of Damask rose using aromatherapy in different painful conditions , the results are inconclusive . Hence , this systematic review and metaanalysis aimed to clarify the effect of aromatherapy with Damask rose on adults ' acute pain .
Material and methods : The online databases of MEDLINE / PubMed , Scopus , ISI web of science , Embase , ProQuest , CENTRAL , CINAHL , SID , and MagIran were searched up to August 10 , 2020 . The aim of this study was to find randomized controlled trials on the effect of aromatherapy with Damask rose in any form of administration ( inhalation , vapor diffusion , and massage ) on different types of acute pain in adults . The Cochrane risk of bias tool was used to assess the methodological quality of the included studies . Moreover , the quality of the evidence was evaluated by the Grading of Recommendations Assessment , Development and Evaluation ( GRADE ) approach . Random effects model was applied to pool data using Stata .
Results : A total of 16 studies met the inclusion criteria , of which only one was not included in the meta-analysis . Pooled analysis revealed that aromatherapy with Damask rose reduced the pain severity significantly ( WMD : -2.12 ; 95 % CI [ -2.85 ,
-1.40 ]; P < 0.001 ). Inhalation aromatherapy ( WMD : -2.39 ; 95 % CI [ -3.31 , -1.48 ]; P < 0.001 ) and aromatherapy massage ( WMD : -1.16 ; 95 % CI [ -1.57 , -0.75 ]; P < 0.001 ) also had significant effects on pain reduction . The quality of evidence was low .
Conclusion : Aromatherapy with Damask rose had a favourable effect on reducing the severity of acute pain in adults . However , there is insufficient evidence for the clinical benefits of aromatherapy with Damask rose due to the low-quality evidence . Accordingly , more high quality randomized clinical trials are needed to make an evidence-based conclusion .
Herbal medicine
Masnadi Shirazi , K ., Shirinpour , E ., Masnadi Shirazi , A . et al .
Effect of cranberry supplementation on liver enzymes and cardiometabolic risk factors in patients with NAFLD : a randomized clinical trial . BMC Complement Med Ther , 2021 ; 21 , 283 . https :// doi . org / 10.1186 / s12906-021-03436-6
Background : We aimed to evaluate the effect of cranberry supplementation on serum liver enzymes , hepatic steatosis , and cardiometabolic risk factors in patients with non-alcoholic fatty liver ( NAFLD ).
Methods : In the present parallel-designed randomized controlled clinical trial , 110 patients with NAFLD were enrolled . The patients were randomized to receive 144 mg cranberry capsule or placebo for 6 months . The primary efficacy of the treatment was lipid profile , glycemic measurements , and liver enzyme levels .
Results : The data were reported for 46 in the supplementation group and 48 in the placebo group . The patient ’ s mean ( SD ) age was 43.16 ( 11.08 ) years . No significant differences between groups were observed regarding the post-intervention level of liver enzyme . The mean afterintervention levels of total cholesterol ( p < 0.001 ) and triglyceride ( p = 0.01 ) were significantly lower in the intervention group compared with the placebo group . At the end of the study , the mean insulin and HOMA-IR levels were significantly lower in the cranberry group compared with the placebo group . Significantly more patients in the cranberry group experienced a decrease in steatosis level compared with the control group .
Conclusion : The results of the present study showed that cranberry supplementation had a positive effect on some lipid profiles , insulin resistance , and hepatic steatosis in patients with NAFLD .
Jayawardena R , Francis TV , Abhayaratna S . et al .
The use of Caralluma fimbriata as an appetite suppressant and weight loss supplement : a systematic review and meta-analysis of clinical trials . BMC Complement Med Ther , 2021 ; 21 , 279 . https :// doi . org / 10.1186 / s12906-021-03450-8
Background : Obesity prevalence has increased during the past few decades , causing a pandemic with an influx in other co-morbidities . Many factors influence weight gain in an obesogenic environment therefore strategies for treating obesity may vary from conventional dietary and physical activity interventions to pharamacotherapy . A shift in unconventional strategies as herbal products for treating obesity have been investigated and one such plant extract is Caralluma fimbriata ( C . fimbriata ). Further , the studies included were systematically reviewed to gather evidence on potential effects of C . fimbriata as an appetite suppressant and weight loss supplement .
Methods : A systematic review of clinical trials reporting the effects of C . fimbriata as appetite suppression and anti-obesity supplement was reported according to PRISMA guidelines . Data were obtained by searching three databases : PubMed ®, Web of Science ® and SciVerse Scopus ® for studies published until 30th April 2020 .
Results : A total of 7 articles studying C . fimbriata satisfied the inclusion and exclusion criteria and were sourced from various countries including Australia ( 3 ), Cuba ( 1 ), India ( 2 ) and Spain ( 1 ). Almost all studies recruited adults who were
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