Cautions and contraindications 90-92
• CoQ10 / ubiquinol is present naturally in the human body . Supplements are generally well-tolerated with only minor and infrequent adverse effects , including mild insomnia , stomach upset , nausea , vomiting and diarrhoea .
These effects may be minimised if doses > 100 mg are divided into two or three daily doses .
• There have been no reports of significant adverse side-effects of oral supplementation at doses as high as 3000 mg / day for up to 8 months , 1200 mg / day for up to 16 months and 600 mg / day for up to 30 months .
• According to the observed safe level ( OSL ) risk assessment method , evidence of safety is strong with doses up to 1200 mg / day of CoQ10 .
• During pregnancy , the use of CoQ10 supplements ( 100 mg twice daily ) from 20 weeks ' gestation was found to be safe .
• Because reliable data in lactating women are not available , supplementation should be avoided during breastfeeding .
• CoQ10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects , which could decrease the effects of warfarin . However , this has been reported in only 4 cases of concomitant use with warfarin .
Patients on warfarin should consult the healthcare provider managing their anticoagulant therapy . If to be used concomitantly , blood tests to assess clotting time ( prothrombin time ; PT / INR ) should be monitored frequently , especially in the first two weeks .
Stephanie Berglin is a practising nutritionist / herbalist in Maroubra , Sydney , where she also contracts to leading natural health supplement companies including Kaneka Ubiquinol™ . Kaneka Corporation is the sole global supplier of evidence-based Kaneka Ubiquinol™ , supported by 100 + scientific studies , 80 + patents and 45 + years of research for mitochondrial health .
REFERENCES For a full list of references , please email the Editor : editor @ atms . com . au
SPECIAL ISSUE CALL FOR PAPERS
Natural Medicine Approaches to Autoimmune Disease
The Journal of the Australian Traditional-Medicine Society ( JATMS ) welcomes submissions to a special-themed issue on natural medicine approaches to auto-immune disease .
Autoimmune diseases occur when the immune system mistakenly damages healthy cells in the body . Types of autoimmune disease include rheumatoid arthritis , psoriasis , Crohn ’ s disease , lupus and some thyroid conditions . 1 Autoimmune diseases are estimated to affect about one in ten individuals , and the burden of these disease can increase over time at varying rates . 2 Natural medicine approaches to managing autoimmune diseases include acupuncture , herbal and nutritional remedies , essential oils , mindfulness and yoga .
The Journal welcomes submissions describing natural medicine approaches to autoimmune disease . These can include articles based on clinical experience , case studies , literature reviews , and articles of original research .
SUBMISSIONS DUE BY : 25 OCTOBER , 2024 editor @ atms . com . au
REFERENCES 1 . Mayo Clinic . Autoimmune disease . Available from : https :// my . clevelandclinic . org / health / diseases / 21624-autoimmune-diseases . Accessed 17 August , 2024 .
2 . The Lancet . Incidence , prevalence , and co-occurrence of autoimmune diseases . Available from : https :// www . thelancet . com / journals / lancet / article / PIIS0140-6736 ( 23 ) 00457-9 / abstract #:~: text = Autoimmune % 20diseases % 20affect % 20approximately % 20one , varying % 20rates % 20across % 20individual % 20diseases . Accessed 17 August , 2024 .