glutamine , probiotics , lactoferrin , and water in the management of chronic fatigue syndrome .
Chronic fatigue syndrome
Chronic fatigue syndrome can affect any age group , 3 with the average age of onset mainly affecting adults from 20 to 40 years of age . 4 The symptoms of chronic fatigue syndrome also affect children , adolescents , and older adults . 4 It has a 2-3 times higher prevalence in women than men . 3 , 4 It is fundamentally characterised by intense fatigue of unknown origin or cause . 4 Chronic fatigue syndrome typically occurs acutely and sometimes suddenly , usually in a previously healthy person . 4 People report having been healthy before the onset of symptoms , being fully functional and with an active social life . 5 Initially , the symptom picture starts with fever , sore throat , cough , muscular pain , headache , and fatigue . 4
There is difficulty in concentrating 4 , 6 and either insomnia or hypersomnia . 4 The course of chronic fatigue fluctuates , with symptom severity changing drastically only in a few days . 5 The typical duration is of at least 6 months . 7 Chronic fatigue syndrome worsens with physical and emotional stress 4 and does not improve with rest . 1 , 4 , 6 , 7 , 32
Chronic fatigue syndrome is a multi-systemic condition 5 that affects the central nervous system , 6 nervous system , 5 immune system , 5 , 6 , 33 digestive system , 5 , 6 cardiovascular system , 6 musculoskeletal system , 4 , 6 , 7 cognition , 3 , 4 , 6 endocrine system , 5 and affects cell energy metabolism . 6 There is ion transport dysfunction , impaired mitochondrial metabolism 6 and function , 5 inflammation , 5 , 6 , 33 increased reactive oxygen species , 6 oxidative stress , 5 decreased antioxidant capacity , 34
deregulation of glycolysis and urea cycle activity , 35 and altered adenosine triphosphate ( ATP ) homeostasis . 6
A common feature of the fatigue is a “ sense of energy depletion ”. 36 Mental and physical fatigue are experienced when a sufficient amount of energy does not meet the brain ’ s and muscles ’ ongoing demands , respectively . 36 The fatigue can be seen as permanent and limits a person ’ s functional capacity , producing various degrees of disability , 4 which limits activities , such as those with family , 1 , 4 work , 1 , 3 , 4 education , 3 and social activities . 1 , 3 , 4 There is a prolonged exacerbation of post-activity fatigue that is triggered by tasks previously achieved without difficulty . 37 If a person with chronic fatigue syndrome overexerts themselves , they have what is termed “ payback ” resulting in a worsening of symptoms or a relapse lasting for days ,
Formulated Nervous System Support
Contains calmative ingredients as traditionally used in Ayurvedic and Western Herbal Medicine .
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