RECENT RESEARCH
Meta-regression and subgroup analyses were conducted based on six covariates ( total sample size , the mean age , the mean dose , the duration of intervention , the oral form of garlic , and the dietary intervention ).
Results : Results from 19 RCTs were included engaging 999 participants . Compared to placebo , garlic significantly reduced TG [ SMD ( 95 % CI ) = -0.66 ( -1.23 , -0.09 )], TC [ SMD ( 95 % CI ) = -0.43 ( -0.86 , -0.01 )], LDL [ SMD ( 95 % CI ) = -0.44 ( -0.88 , -0.01 )], DBP [ SMD ( 95 % CI ) = -1.33 ( -2.14 , -0.53 )], BMI [ SMD ( 95 % CI ) = -1.10 ( - 1.90 , -0.20 )], and WC [ SMD ( 95 % CI ) = -0.78 ( -1.09 , -0.47 )]. Metaregression showed age and sample size are potential effect modifiers .
Conclusion : According to the results of meta-analysis , the modulatory effect of garlic on some MetS components is evident . More high-quality , large-scale RCTs are needed to confirm iat based on the high heterogeneity and potential publication bias of the current data .
Trial registration : https :// www . crd . york . ac . uk / prospero / display _ record . php ? RecordID = 373228 , ID : CRD42022373228 .
Saber A , Abedimanesh N , Somi M-H , Khosroushahi AY , Moradi S . Anticancer properties of red beetroot hydro-alcoholic extract and its main constituent ; betanin on colorectal cancer cell lines . BMC Complementary Medicine and Therapies . 2023 ; 23 , Article number : 246 .
Colorectal cancer ( CRC ) is the third most common type of cancer worldwide . Red beetroot ( Beta vulgaris ) contains Betanin as its major betacyanin , possessing wide proapoptotic effects . This study aimed to investigate the anticancer and pro-papoptotic effects of beetroot hydro-alcoholic extract ( BHE ) and betanin , on colorectal cancer cell lines . BHE and betanin were used to treat Caco-2 and HT-29 colorectal cancer cells . MTT assay , DAPI staining , and FACS-flow cytometry tests were used to determine the half-maximal inhibitory concentration ( IC50 ) and apoptosisinducing evaluations . Intended genes were assessed by real-time polymerase chain reaction ( RT-PCR ). The IC50 for HT-29 and Caco-2 cell lines were 92 μg / mL , 107 μg / mL for BHE , and 64 μg / mL , 90 μg / mL for betanin at 48 h , respectively . BHE and betanin significantly inhibited the growth of both cancer cell lines time and dosedependently . DAPI staining and flow cytometry results revealed significant apoptosis symptoms in treated cancerous cell lines . The expression level of proapoptotic genes ( BAD , Caspase-3 , Caspase-8 , Caspase-9 , and Fas-R ) in treated HT-29 and Caco-2 cells was higher than in untreated and normal cells . In contrast , the anti-apoptotic gene ( Bcl-2 ) was significantly downregulated . BHE and betanin effectively inhibited cancer cell proliferation and induced apoptosis via the modification of effective genes .
Lange KW , Lange KM , Nakamura Y , Reissmann A . Nutrition in the Management of ADHD : A Review of Recent Research . Curr Nutr Rep . 2023 . doi : 10.1007 / s13668-023-00487-8 .
Purpose of review : Various nutrients and diet quality have been suggested to be involved in the pathophysiology of ADHD . The purpose of this review was to examine data from recent cohort studies and dietary interventions to determine whether nutrition may play a role in the management of ADHD .
Recent findings : Preliminary evidence suggests that minerals might have beneficial effects on ADHD symptomatology . Probiotics might offer novel strategies to prevent or treat ADHD . Inverse associations between adherence to " healthy " diets and ADHD symptoms have been observed . Children with ADHD responding to the fewfoods diet ( or oligoantigenic diet ) with an elimination of individually identified food items show substantially improved behavior and cognitive functioning . Evidence from recent research does not allow any recommendations regarding the use of micronutrients or probiotics in the management of ADHD . The few-foods diet may become an additional therapeutic option for children with ADHD .
Paoli A , Bianco A , Moro T , Mota JF , Coelho- Ravagnani CF . The Effects of Ketogenic Diet on Insulin Sensitivity and Weight Loss , Which Came First : The Chicken or the Egg ? Nutrients . 2023 Jul 12 ; 15 ( 14 ): 3120 . doi : 10.3390 / nu15143120 . PMID : 37513538 ; PMCID : PMC10385501 .
The ketogenic diet ( KD ) is , nowadays , considered an interesting nutritional approach for weight loss and improvement in insulin resistance . Nevertheless , most of the studies available in the literature do not allow a clear distinction between its effects on insulin sensitivity per se , and the effects of weight loss induced by KDs on insulin sensitivity . In this review , we discuss the scientific evidence on the direct and weight loss mediated effects of KDs on glycemic status in humans , describing the KD ' s biochemical background and the underlying mechanisms .
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