RECENT RESEARCH
distances . Past research has found that telemedicine can play a role in enhancing complementary , alternative , and integrative medicine ( CAIM ) while allowing the maintenance of cultural values and ancestral knowledge . This scoping review synthesized evidence regarding the use of telemedicine in the context of CAIM .
Methods : Following Arksey and O ’ Malley ’ s scoping review framework , CINAHL , PsycINFO , MEDLINE , EMBASE and AMED databases were searched systematically . The CADTH website was also searched for grey literature . Eligible articles included a CAIM practice or therapy offered through telemedicine , with no restrictions placed on the type of telemedicine technology used . Inductive thematic analysis was conducted to synthesise common themes among the included studies .
Results : Sixty-two articles were included in this synthesis . The following themes emerged : 1 ) the practitioner view of CAIM delivered through telemedicine , 2 ) the patient view of CAIM delivered through telemedicine , and 3 ) the technological impacts of telemedicine delivery of CAIM .
Conclusions : Studies have shown that telemedicine delivery of CAIM is feasible , acceptable , and results in positive health outcomes . Some barriers remain such as the presence of chronic illness and morbidity , inability to form strong patient-provider relationships relative to face-to-face approaches , and technological difficulties . Future intervention research should focus on reducing such barriers , as well as explore which patient population would realize the greatest benefit from CAIM delivered via telemedicine , and the impact of interventions on providers and caregivers .
Herbal medicine
Yu W , Gao Y , Zhao Z , Long X , Yi Y , Ai S . Fumigaclavine C ameliorates liver steatosis by attenuating hepatic de novo lipogenesis via modulation of the RhoA / ROCK signaling pathway . BMC Complementary Medicine and Therapies . 2023 ; 23 , Article number : 288 .
Background : Non-alcoholic fatty liver disease ( NAFLD ) has been well defined as a common chronic liver metabolism disorder . Statins as a first-line therapeutic treatment had some side effects . Here , we found that Fumigaclavine C ( FC ) was collected from endophytic Aspergillus terreus via the root of Rhizophora stylosa ( Rhizophoraceae ), had potential anti-adipogenic and hepatoprotective effects both in vitro and in vivo without obvious adverse side effects . However , the mechanisms of the prevention and management of FC for hepatic steatosis are incompletely delineated .
Methods : The pharmacodynamic effects of FC were measured in high-fat diet ( HFD ) -induced obese mice . Liver index and blood biochemical were examined . Histopathological examination in the liver was performed by hematoxylin & eosin or oil red O . The levels of serum TG , TC , LDL-c , HDL-c , FFA , T-bili , ALT , AST , creatinine , and creatine kinase were estimated via diagnostic assay kits . The levels of hepatic lipid metabolism-related genes were detected via qRT-PCR . The expression levels of hepatic de novo lipogenesis were quantitated with Western blot analysis .
Results : FC-treatment markedly reduced hepatic lipid accumulation in HFD-induced obese mice . FC significantly attenuated the hepatic lipid metabolism and ameliorated liver injury without obvious adverse side effects . Moreover , FC also could dosedependently modulate the expressions of lipid metabolism-related transcription genes . Mechanically , FC notably suppressed sterol response element binding protein-1c mediated de novo lipogenesis via interfering with the RhoA / ROCK signaling pathway by decreasing the levels of geranylgeranyl diphosphate and farnesyl diphosphate .
Conclusions : These findings suggested that FC could improve hepatic steatosis through inhibiting de novo lipogenesis via modulating the RhoA / ROCK signaling pathway .
Li Y , Wang L , Zhang J , Xu B , Zhan H . Integrated multi-omics and bioinformatic methods to reveal the mechanisms of sinomenine against diabetic nephropathy . BMC Complementary Medicine and Therapies . 2023 ; 23 , Article number : 287 .
Objectives : Diabetic Nephropathy ( DN ) is a serious complication of diabetes , the diagnosis and treatment of DN is still limited . Sinomenine ( SIN ) is an active extract of herbal medicine and has been applied into the therapy of DN .
Methods : In the part of bioinformatic analyses , network pharmacology and molecular docking analyses were conducted to predict the important pathway of SIN treatment for DN . Invivo study , DN rats were randomized to be treated with vehicle or SIN ( 20 mg / kg or 40 mg / kg ) daily by gavage for 8 weeks . Then , the pharmacological effect of SIN on DN and the potential mechanisms were also evaluated by 24 h albuminuria , histopathological examination , transcriptomics , and metabolomics .
Results : Firstly , network pharmacology and molecular docking were performed to show that SIN might improve DN via AGEs / RAGE , IL-17 , JAK , TNF pathways . Urine biochemical parameters showed that SIN treatment could significantly reduce 24 h albuminuria of DN rats . Transcriptomics analysis found SIN could affect DN progression via inflammation and EMT pathways . Metabolic pathway analysis found SIN would mainly involve in arginine biosynthesis , linoleic acid metabolism , arachidonic acid metabolism , and glycerophospholipid metabolism to affect DN development .
Conclusions : We confirmed that SIN could inhibit the progression of DN via affecting multiple genes and metabolites related pathways .
Delam H , Keshtkaran Z , Shokrpour N , Eidi A , Bazrafshan M-R . The effect of Crocus sativus L . ( saffron ) herbal tea on happiness in postmenopausal women : a randomized controlled trial . BMC Complementary Medicine and Therapies . 2023 : 23 , Article number : 176 .
166 | vol29 | no3 | JATMS