administered the indicated homeopathic medicine in the 200th potency in infrequent repetition while 35 children from Group II were given placebo . The children and the Remedial Educators who were the assessors were blinded for the study . The researchers found that the children under homeopathic treatment with remedial education , when compared to the control group , showed an earlier response to remedial inputs and a statistically significant change in the indicators of dyslexia and dysgraphia . There was also a significant change in the co‐morbid behavioural condition notably Attention Deficit Hyperactivity Disorder ( ADHD ).
5 . Jacobs J , Taylor JA . A randomized controlled trial of a homeopathic syrup in the treatment of cold symptoms in young children . Complement Ther Med , 2016 , 29 , 229-34 . This study was conducted to determine if a homeopathic syrup was effective in treating cold symptoms in preschool children . Children 2-5 years old diagnosed with an upper respiratory tract infection were randomised to receive a commercial homeopathic cold syrup or placebo . Parents administered the study medication as needed for 3 days . The primary outcome was a change in symptoms 1 hour after each dose . Parents also assessed the severity of each of the symptoms of runny nose , cough , congestion and sneezing at baseline and twice daily for 3 days , using a 4-point rating scale . A composite cold score was calculated by combining the values for each of the 4 symptoms . Among 261 eligible participants , data on 957 doses of study medication in 154 children were analysed . Analysis of twice daily data on the severity of cold symptoms compared to baseline values found that improvements in sneezing , cough and the composite cold score were significantly greater in the first day after beginning treatment among those receiving the cold syrup compared to placebo recipients .
6 . Chakraborty D , et al . A comparative study of homoeopathic medicine – Sulphur with the Multidrug therapy in the treatment of paucibacillary leprosy .
Indian J Res Homeopathy , 2015 , 9 , 158-66 . Workers in this study sought to compare the effect of a homeopathic medicine , Sulphur , with standard pharmaceutical therapy in the treatment of paucibacillary leprosy according to WHO guidelines . Sixty people with confirmed Borderline Tuberculoid ( BT ) leprosy , aged 14 to 60 years , were enrolled in the trial . All patients were randomly and equally divided in 2 groups . One group was treated with Sulphur in 200 potency in liquid orally once in week for 2 years and the other group received Paucibacillary ( PB ) regimen as recommended by WHO . Assessment was carried out via a histopathological analysis of the affected skin . At the end of 2 years the results showed that standard pharmaceutical therapy and homeopathic medicine were found equally effective in relieving paucibacillary leprosy . The most significant clinical sign observed in all cases treated with Sulphur was the reappearance of normal skin colour and a recovery from the loss of sensation of the skin lesion .
Plant Studies
1 . Betti L , et al . Number of succussion strokes affects effectiveness of ultrahigh-diluted arsenic on in vitro wheat germination and polycrystalline structures obtained by droplet evaporation method . Homeopathy , 2017 , 106 , 1 , 47-54 . The aim here was to investigate whether the number of succussion strokes applied after each dilution step when preparing homeopathic treatments influences the effectiveness of ultra-high-diluted ( UHD ) arsenic trioxide at the 45th decimal dilution / dynamisation ( As2O3 45X ). To do this , wheat seeds , previously stressed with ponderal As2O3 , were treated with : As2O3 45X , H2O 45X ( dynamised control ), or pure water ( negative control ). The succussion was done manually , and various succussion durations ( numbers of strokes ) were tested for each treatment . Treatment effectiveness was tested blind using the in vitro germination test and the droplet evaporation method ( DEM ). Data were processed by the Poisson test ( germination test ) and by two-way analysis of variance
( DEM ). The team evaluated both the in vitro germination rate , by counting the non-germinated seeds , and the complexity of polycrystalline structures ( PCS ) ( local connected fractal dimension ( LCFD )) obtained by evaporating leakage droplets from stressed seeds that had been watered with the different treatments . A highly significant increase in germination rate was noted when the number of strokes ( NS ) was ≥32 for both As2O3 45X and H2O 45X , and a significant increase in the LCFD of PCS for As2O3 45X when the NS was ≥32 and for H2O 45X when it was 70 . Both experimental approaches showed increased effectiveness for treatments prepared with a higher number of succussion strokes .
In vitro Studies
1 . Olsen S . Effects of ultra-high dilutions of sodium butyrate on viability and gene expression in HEK 293 cells . Homeopathy , 2017 , 106 , 1 , 32-36 . Recent research has reported the capability of homeopathic medicines to modulate gene expression in cell cultures and this study examined whether ultrahigh dilutions ( 30C and 200C ) of sodium butyrate ( SB ) can affect the expression levels of genes involved in the acquisition of a senescence-associated secretory phenotype ( SASP ) in human embryonic kidney ( HEK ) 293 cells . Cell viability was evaluated using a 3- [ 4,5-dimethylthiazol- 2-yl ] -2,5-diphenyltetrazolium bromide ( MTT ) assay . The expression levels of TNF-α , interleukin ( IL ) -2 , IL-4 , IL-6 and IL-10 genes were determined by real-time PCR assay . Exposure to both 30C and 200C SB over 48 hours led to a significant decrease of the level of expression of TNF-α gene , while expression of IL-2 gene was increased when exposed to 30C SB , and expression of IL-10 gene was decreased when exposed to 200C SB . No changes in expression levels of genes were observed in cells treated with both 30C and 200C SB during the first 24 hours . The observed changes in gene expression levels after exposure to 30C and 200C SB during 48 hours suggest that extremely low concentrations of this agent can modulate the transcription of HEK 293 cells .
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