Dependence Questionnaire [ SADQ ] rating scale at 12 months . Data analysis was done for both intention‐to‐treat ( ITT ) and per‐protocol ( PP ) populations . The results showed that IH was superior to SA in the management of alcohol dependence . The medicines most frequently used were Sulphur , Lycopodium clavatum , Arsenicum album , Nux vomica , Phosphorus , and Lachesis .
3 . Palm J , et al . Effectiveness of an add-on treatment with the homeopathic medication SilAtro-5-90 in recurrent tonsillitis . Complement Ther Clin Pract . 2017 ; 28:181-91 . In this international , pragmatic , controlled clinical trial , 256 patients ( 6-60 years ) with moderate recurrent tonsillitis were randomised to receive either SilAtro-5-90 , a homeopathic combination , in addition to standard symptomatic treatment , or standard treatment only . The primary outcome was the mean time period between consecutive acute throat infections ( ATI ) within 1 year ( analysed via repeated events analysis ). During the evaluation year , the risk of getting an ATI was significantly lower ( hazard ratio : 0.45 , proportional means model , p = 0.0002 , ITT ) with SilAtro-5-90 compared to control . Tonsillitisspecific symptoms were significantly reduced ( p < 0.0001 , ITT ) and the need of antibiotics to treat acute throat infections ( p = 0.0008 ; ITT ) decreased .
4 . Motiwala FF , et al . Effect of Homoeopathic treatment on Activity of Daily Living ( ADL ) in Knee Osteoarthritis : A prospective observational study . Indian J Res Homoeopathy . 2016 ; 10:182-7 . An Indian research team set out to investigate the effect of individualised homeopathic medicines in improving ADL in knee osteoarthritis ( OA ) patients by reducing pain and stiffness , and limiting the disease progress . A total of 131 consecutive patients with OA of the knee were recruited and followed up for minimum period of 12 months . Two orthopaedic surgeons diagnosed the disease based on clinical examination of the patients . Three trained homeopathic physicians prescribed individualised homeopathic medicines and the patients were evaluated for pain on WOMAC Osteoarthritis Index LK3.1 ( IK ) survey form measuring pain , stiffness and ADL . The pain was also measured on Numerical pain rating scale ( NRS ) for further confirmation . The homeopathic intervention was associated with a mean ADL score reduction of 35.85 down to 19.08 ( p‐ . 0.0001 ). Mean pain on WOMAC Osteoarthritis Index survey form improved from 10.50 to 5.48 ( p‐0.0001 ). The mean pain score on NRS improved from 6.34 to 3.77 ( p‐0.0001 ) and the mean morning stiffness also improved from 4.55 to 2.18 ( p‐0.0001 ).
5 . Sorrentino L , et al . Is there a role for homeopathy in breast cancer surgery ? A first randomized clinical trial on treatment with Arnica montana to reduce post-operative seroma and bleeding in patients undergoing total mastectomy . J Intercult Ethnopharmacol . 2017 ; 6 ( 1 ): 1-8 . This study aimed to evaluate the benefits of homeopathically prepared Arnica montana on postoperative blood loss and seroma production in women undergoing unilateral total mastectomy by administering Arnica Montana 1000 Korsakovian dilution ( 1000 K ). From 2012 to 2014 , 53 women were randomly assigned to A . montana or placebo and were followed for up for 5 days . The main end point was the reduction in blood and serum volumes collected in drainages . Secondary end points were duration of drainage , a self-evaluation of pain , and the presence of bruising or hematomas . The results showed that the use of Arnica 1000 K was associated with a reduced post-operative blood and seroma collection .
6 . Mittal R , et al . An open‐label pilot study to explore usefulness of Homoeopathic treatment in nonerosive gastroesophageal reflux disease . Indian J Res Homoeopathy . 2016 ; 10:188-98 . This was a pilot study undertaken to explore the effect of homoeopathic medicines in the treatment of people with non-erosive gastrooesophageal reflux disease ( GORD ) or non-erosive reflux disease ( NERD ). A total of 34 people were enrolled , having symptoms of heartburn and / or regurgitation at least twice a week , and having a GORD symptom score of more than 4 . Homoeopathic medicine was prescribed on the basis of the presenting symptoms . Response to treatment was assessed on GORD symptom score , visual analogue scale ( VAS ) for heartburn , and the World Health Organisation quality of life‐BREF ( WHO‐QOL ) questionnaire evaluated at baseline and at the end of 8 weeks of treatment . Significant differences were found in pre- and posttreatment GORD symptom score ( 8.79 ± 2.7 vs . 0.76 ± 1.8 ; P = 0.001 ) and the VAS for heartburn ( 47.47 ± 19.6 vs . 5.06 ± 11.8 ; P = 0.001 ). Statistically significant improvement was also seen in three domains of the WHO‐QOL score ( i . e . psychological health , social relationship , and environmental domain ).
In-Vitro Studies
1 . Ganesan T , et al . Homoeopathic preparation of Berberis vulgaris as an inhibitor of Calcium oxalate crystallization : In-vitro evidence . Indian J Res Homeopathy . 2015 ; 9:152-7 . The aim here was to examine the potential role of the homeopathic preparation of B . vulgaris ( mother tincture , 6C , 30C and 200C ) on in-vitro Calcium oxalate ( CaOx ) crystallisation . Spectrophotometric crystallisation assay was carried out , and the slopes of the nucleation ( till the maximum ) and aggregation ( after the peak ) phases were calculated using linear regression analysis , and the percentage inhibition exerted by the modifiers was calculated . Light microscopic observation of CaOx crystals formed in the presence or absence of modifiers was carried out to support the spectrophotometric
28 | vol30 | no1 | JATMS