RECENT RESEARCH
group , a 30-min Swedish massage was performed regularly for eight weeks : twice a week for the first four weeks , and three times a week for the last four weeks . The control group received routine care . The visual analogue scale-pain was used to measure pain in the two groups at three points of time : before the beginning of the experiment , immediately after the last session , and one month after the last session of the intervention .
Results : The analysis of covariance showed that there were significant differences between the two groups ' mean scores of pain and painkiller consumption immediately after and one month after the last session of the intervention ( p = 0.01 ). Furthermore , in the experimental group , the mean scores of pain and painkiller consumption decreased over the three points of time ( p < 0.05 ).
Conclusion : Swedish massage can be effective in reducing pain and the need to use painkillers in rheumatoid arthritis patients . Highlights : In the present study , Swedish massage was effective in reducing pain in patients with rheumatoid arthritis . Based on our results , Swedish massage can decrease painkiller consumption in rheumatoid arthritis patients . Swedish massage can be a safe and effective intervention for managing pain in rheumatoid arthritis patients .
Du J , Yuan Q , Wang Z-Y , Qian J-H , An J , Dai Q , Yan X-Y , Xu B , Lui J , Want H-Y . Manual Therapy and Related Interventions for Carpal Tunnel Syndrome : A Systematic Review and Meta-Analysis . Journal of Integrative and Complementary Medicine . 2022 ; 28 ( 12 ). https :// doi . org / 10.1089 / jicm . 2022.0542
Objective : Systematic review and metaanalysis to assess the efficacy of Manual therapy and related interventions in the treatment of carpal tunnel syndrome ( CTS ) based on Boston carpal tunnel questionnaire .
Design : Systematic review and metaanalysis .
Subjects : Carpal tunnel syndrome .
Interventions : Manual therapy and related interventions versus other therapies or manual therapy and related interventions plus other therapies versus other therapies .
Outcomes measures : Boston carpal tunnel questionnaire .
Results : A total of 6 studies were included , including 211 cases in the manual therapy group and 211 cases in the control group . The quality of the included articles was high , and the results of meta-analysis showed that manual therapy and related interventions were superior in terms of improving the Boston carpal tunnel questionnaire Symptom Severity score in patients with CTS ( standardised mean difference [ SMD ] −1.13 , 95 % CI −1.40 to −0.87 ), were superior to control groups in terms of improving the Boston carpal tunnel questionnaire functional capacity scale in patients with CTS ( SMD −1.01,95 % CI −1.24 to −0.77 ).
Conclusion : The results of this metaanalysis suggested that manual therapy and related interventions were better than control groups in treating CTS . Manual therapy and related interventions could relieve the symptoms of patients with CTS and promote the recovery of hand function . Manual therapy and related interventions should be considered clinically effective methods for treating CTS .
Naturopathy
Premarathna AD , Tuvikene R , Somasiri MNR , De Silva MLWP , Adhikari R , … RP Rajapakse . A novel therapeutic effect of mannitol-rich extract from the brown seaweed Sargassum ilicifolium using in vitro and in vivo models . BMC Complementary Medicine and Therapies . 2023 , 23 , Article number : 26 .
Background : Wound healing is an active , complex , integrated series of cellular , physiological , and biochemical changes initiated by the stimulus of injury in a tissue . The present study was performed to investigate the potential wound healing abilities of Sargassum ilicifolium crude extracts ( CE ) that were characterized by 1H NMR and FTIR Spectrometric measurements .
Materials and methods : Seaweed samples were collected from southern coastal sites of Sri Lanka . To determine the cytotoxicity and proliferation of S . ilicifolium CE were used for the MTT and alamarBlue assays respectively . The scratch and exclusion wound models were used to HaCaT and HDF cells to assess the cell proliferation and migration . RAW 264.7 cells ( macrophages ) were used to evaluate Nitric Oxide ( NO ) production and phagocytosis activities . Moreover , Fifteen , 8-week-old , female , New Zealand rabbits were selected and divided into five groups : excision skin wounds ( 10.40 ± 0.60 mm ) were induced in groups I , II , and III . Rabbits in groups I and IV were given S . ilicifolium CE ( orally , 100 mg / kg day , two weeks ), whereas groups II and V were given equal amounts of distilled water . Wound healing properties were measured and wound tissue samples were collated , formalin-fixed , wax-embedded , stained ( Hematoxylin and Eosin ; Van Gieson ) and examined for the healing process .
Results : Anti-inflammatory and wound healing activities were observed in RAW 264.7 , HDF and HaCaT cells treated with S . ilicifolium aqueous extracts when compared to the control groups . S . ilicifolium extracts concentration 8 - 4 μg / μL , ( P < 0.05 ) had remarkable the highest proliferative and migratory effects on RAW 264.7 , HDF and HaCaT cells when compared with the control . RAW 264.7 cell proliferation and / or migration were higher in S . ilicifolium extracts ( 4 μg / μL , 232.8 ± 10.07 %) compared with the control ( 100 %). Scratch wound healing were remarkably enhanced in 24 h , 48 h ( P < 0.05 ) when treated with S . ilicifolium on HaCaT cells . Rabbits treated with the CE of S . ilicifolium showed a significantly increased wound healing activities ( P < 0.05 ) within three days with a close wound area of 57.21 ± 0.77 % compared with control group ( 26.63 ± 1.09 %). Histopathology , aspartate aminotransferase and alanine aminotransferase levels evidenced no toxic effects on seaweed treated groups .
48 | vol29 | no1 | JATMS