Great Strides in CML Survivorship
Couch Potatoes Are No Small Potatoes
CLINICAL NEWS
Great Strides in CML Survivorship
With the introduction of tyrosine kinase inhibitors and allogeneic hematopoietic cell transplantation , patients with chronic myeloid leukemia ( CML ) now have life expectancies approaching that of the general population .
Swedish researchers at the Karolinska Institute evaluated the life expectancy for 2,662 patients diagnosed with CML between 1973 and 2013 . Life expectancy steadily increased during the entire study period , with a more dramatic increase after 1990 – especially among younger patients .
Couch Potatoes Are No Small Potatoes
The global epidemic of physical inactivity carries a heavy disease burden ( being associated with a range of chronic diseases and early deaths ), but the economic burden may be just as weighty .
Research published in The Lancet estimated the global direct and indirect costs ( including productivity losses and disability-adjusted life-years ) in 2013 for patients from 142 countries with one of the five major inactivity-related diseases : coronary heart disease , stroke , type 2 diabetes , breast cancer , and colon cancer .
Average life expectancy after diagnosis for a 55-yearold man with
CML :
3.5 years in 1980
27.3 years in 2010
Globally , direct and indirect costs totaled
$
67.5 BILLION including
$
53.8 BILLION
$
13.7 BILLION
Notably , America ’ s share of these costs was
$
27.8 BILLION or 40 % of the total global costs . in health-care costs and
in indirect costs .
Source : Ding D , Lawson KD , Kolbe-Alexander TL , et al . The economic burden of physical inactivity : a global analysis of major non-communicable diseases . Lancet . 2016 July 27 . [ Epub ahead of print ]
Average life expectancy after diagnosis for an 85-yearold man :
0.8 years in 1980
4.1 years in 2010
Regardless of age , patients diagnosed in 2010 or later are expected to lose less than 3 years of life expectancy as a result of CML .
Source : Bower H , Bjorkholm M , Dickman PW , et al . Life expectancy of patients with chronic myeloid leukemia approaches the life expectancy of the general population . J Clin Oncol . 2016 June 20 . [ Epub ahead of print ]
What Do You Look for in a Blood Donor ?
In an analysis of survival outcomes for 30,503 red blood cell ( RBC ) recipients who received 187,960 transfusions from 80,755 unique blood donors , researchers found that receiving RBC transfusions from older , male donors may lower mortality risk .
Compared with patients who received RBC units from 40- to 49.9-year-old donors , the risk of death was :
|
8 % higher with 17- to 19.9-year-old donors |
6 % higher with 20- to 29.9-year-old donors |
Compared with recipients of RBC units from male donors , the risk of death was 8 % higher with female donors .
Source : Chassé M , Tinmouth A , English SW , et al . Association of blood donor age and sex with recipient survival after red blood cell transfusion . JAMA Intern Med . 2016 July 11 . [ Epub ahead of print ]
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