ASH Clinical News September 2015 | Page 42

In CLL-11, for the first-line treatment of typical* patients, in combination with Clb GAZYVA DEMONSTRATED SUPERIOR PFS vs RITUXIMAB1-4 GAZYVA + CLB DELIVERED A SIGNIFICANT IMPROVEMENT IN MEDIAN PFS COMPARED TO RITUXIMAB + CLB IN FIRST-LINE CLL (26.7 MONTHS VS 14.9 MONTHS) WITH 6 PLANNED CYCLES OF THERAPY1 Proportion progression free 1.0 0.9 0.8 0.7 0.6 0.5 0.4 0.3 0.2 14.9 GAZYVA + Clb (n=333) rituximab + Clb (n=330)