AR TE
YEPDA
5U
99%
OF PATIENTS DID NOT PROGRESS TO AP/BC
AT 5 YEARS vs 95% WITH IMATINIB1*
*Based on Kaplan-Meier estimates of time to progression to AP or BC on core treatment (full analysis set) without clonal evolutions.
Estimated rates of no progression at 5 years: TASIGNA 99.3% (95% CI, 98.2%-100%) vs imatinib 95.2% (95% CI, 92.6%-97.9%).1
PROGRESSION EVENTS TO AP/BC1,2
2
TASIGNA PATIENTS
PROGRESSED TO AP/BC
12
IMATINIB PATIENTS
PROGRESSED TO AP/BC
DIAGNOSIS
6
MONTHS
12
MONTHS
18
MONTHS
24
MONTHS
3
YEARS
4
YEARS
5
YEARS
• No progressions to AP/BC occurred with TASIGNA after the first 6 months2
A HIGHER RATE OF MMR WAS ACHIEVED vs IMATINIB BY 5 YEARS1,2
• 77% of patients reached MMR by 5 years with TASIGNA (95% CI, 72%-82%) vs 60% with imatinib (95% CI, 55%-66%)1,2
• Median time on treatment was approximately 61 months in all treatment arms2
• The cumulative incidence of MMR end point by 5 years includes patients who achieved MMR at any time up to the 60-month cutoff. Subsequent loss
of MMR, patients who did not attain MMR, or those lost to follow-up are not included in this calculation1
FOR MORE INFORMATION AND ACCESS TO SAVINGS FOR ELIGIBLE PATIENTS, PLEASE VISIT WWW.TASIGNA.COM
IMPORTANT SAFETY CONSIDERATIONS
• Fluid Retention: Grade 3/4 fluid retention including pleural effusion, pericardial effusion, ascites and pulmonary edema have been reported in patients
receiving TASIGNA
• ADVERSE REACTIONS: The most commonly reported non-hematologic adverse reactions (≥20% in patients) were nausea, rash, headache, fatigue, pruritus,
vomiting, diarrhea, cough, constipation, arthralgia, nasopharyngitis, pyrexia, and night sweats. Hematologic adverse drug reactions include myelosuppression:
thrombocytopenia, neutropenia and anemia
• DOSE ADJUSTMENTS OR MODIFICATIONS: TASIGNA may need to be temporarily withheld and/or dose reduced for QT prolongation, hematologic toxicities that
are not rel ]Y