Illuminating an underlying cause of hemolytic anemia
Know PK Deficiency
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• Pyruvate kinase ( PK ) is an enzyme critical for maintaining red blood cell energy levels .
• PK deficiency is the most common cause of hereditary nonspherocytic hemolytic anemia , yet may be underrecognized . 1-3
When to Suspect PK Deficiency PK deficiency should be considered in patients with hemolysis and no findings suggestive of an acquired autoimmune process , red cell membrane defect , or hemoglobinopathy . 1
Patient identification and diagnosis are taking on new importance .
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1 . Grace RF , Zanella A , Neufeld EJ , Morton DH , Eber S , Yaish H , Glader B . Erythrocyte Pyruvate Kinase Deficiency : 2015 Status Report . Am J Hematol . 2015 Sep ; 90 ( 9 ): 825-30 .
2 . Zanella A , Fermo E , Bianchi P , Chiarelli LR , Valentini G . Pyruvate kinase deficiency : the genotype-phenotype association . Blood Reviews 2007 : 21 ; 217 – 231 .
3 . Zanella A , Bianchi P . RBC pyruvate kinase deficiency : from genetics to clinical manifestations . Bailliere ’ s Clin Haematol 2000 ; 13:57-81 .
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