CLINICAL NEWS
Twenty-seven patients were diagnosed
with relapsed or refractory disease, and 12
patients died during follow up.
“There was a high degree of correlation
between the two MTV and TLG contouring
methods and, given the greater objectivity as
well as more prevalent use of the threshold
method, we used the MTV t and TLG t for
the analysis,” the authors wrote. Univariate
analyses determined that the following
factors were associated with worse FFP:
• German Hodgkin Study Group
(GHSG) classification, defined as
bulky disease, >2 involved sites, and
extranodal extension (hazard ratio
[HR] = 7.56 for IIB-advanced vs.
favorable [p=0.008] and HR=2.89 for
unfavorable vs. favorable [p=0.086])
• not receiving consolidation
radiotherapy (HR=4.71; p=0.016)
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• total MTV (for every 100-unit
increase in MTV t , HR=1.72;
p<0.0005)
• total TLG (for every 500-unit
increase in TLG t , HR=1.13; p<0.005)
• axial (HR=1.17; p=0.032), sagittal
(HR=1.11; p=0.047), or coronal
(HR=1.16; p<0.005) diameter of the
longest node or nodal conglomerate
Safety and eff ectiveness of
VYXEOS in pediatric patients
have not been established.
IMPORTANT SAFETY INFORMATION, continued
Hypersensitivity Reactions
Serious or fatal hypersensitivity reactions, including
anaphylactic reactions, have been reported with daunorubicin
and cytarabine. Monitor patients for hypersensitivity
reactions. If a mild or moderate hypersensitivity reaction
occurs, interrupt or slow the rate of infusion with VYXEOS
and manage symptoms. If a severe or life-threatening
hypersensitivity reaction occurs, discontinue VYXEOS
permanently, treat the symptoms, and monitor until
symptoms resolve.
Copper Overload
VYXEOS contains copper. Monitor total